Integrating Analysis of Cellular Heterogeneity in High-Content Dose-Response Studies.
Sign Up to like & getrecommendations! Published in 2018 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-7680-5_2
Abstract: Heterogeneity is a complex property of cellular systems and therefore presents challenges to the reliable identification and characterization. Large-scale biology projects may span many months, requiring a systematic approach to quality control to track reproducibility… read more here.
Keywords: heterogeneity; cellular heterogeneity; biology; integrating analysis ... See more keywords
Roles of cellular heterogeneity, intrinsic and extrinsic noise in variability of p53 oscillation
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-41904-9
Abstract: The p53 protein is a key mediator of the cellular response to various stress signals. In response to DNA damage, the concentration of p53 can temporally oscillate with fluctuations in both the amplitude and period.… read more here.
Keywords: p53 variability; variability; cellular heterogeneity; noise ... See more keywords
SimCH: simulation of single-cell RNA sequencing data by modeling cellular heterogeneity at gene expression level
Sign Up to like & getrecommendations! Published in 2022 at "Briefings in bioinformatics"
DOI: 10.1093/bib/bbac590
Abstract: Single-cell ribonucleic acid (RNA) sequencing (scRNA-seq) has been a powerful technology for transcriptome analysis. However, the systematic validation of diverse computational tools used in scRNA-seq analysis remains challenging. Here, we propose a novel simulation tool,… read more here.
Keywords: cell; simch; single cell; simulation ... See more keywords
A multi-view latent variable model reveals cellular heterogeneity in complex tissues for paired multimodal single-cell data
Sign Up to like & getrecommendations! Published in 2023 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btad005
Abstract: Abstract Motivation Single-cell multimodal assays allow us to simultaneously measure two different molecular features of the same cell, enabling new insights into cellular heterogeneity, cell development and diseases. However, most existing methods suffer from inaccurate… read more here.
Keywords: cell; paired multimodal; single cell; multi view ... See more keywords
Applications of single-cell genomics and computational strategies to study common disease and population-level variation.
Sign Up to like & getrecommendations! Published in 2021 at "Genome research"
DOI: 10.1101/gr.275430.121
Abstract: The advent and rapid development of single-cell technologies have made it possible to study cellular heterogeneity at an unprecedented resolution and scale. Cellular heterogeneity underlies phenotypic differences among individuals, and studying cellular heterogeneity is an… read more here.
Keywords: single cell; disease; cellular heterogeneity; cell ... See more keywords
Abstract 3570: Preservation of cellular heterogeneity in 3D and 2D cultures of pediatric solid tumors
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-3570
Abstract: Over the past 10 years, we have developed and characterized over 280 orthotopic patient derived xenografts (O-PDXs) representing 23 different types of pediatric solid tumors. The O-PDXs have undergone comprehensive characterization including genomics, transcriptomics, epigenomics,… read more here.
Keywords: culture; heterogeneity; cell; pediatric solid ... See more keywords
Towards precision medicine: linking genetic and cellular heterogeneity in gastric cancer
Sign Up to like & getrecommendations! Published in 2018 at "Therapeutic Advances in Medical Oncology"
DOI: 10.1177/1758835918794628
Abstract: Molecular and cellular heterogeneity are phenomena that are revolutionizing oncology research and becoming critical to the idea of personalized medicine. Recent comprehensive molecular profiling has identified molecular subtypes of gastric cancer (GC) and linked them… read more here.
Keywords: medicine; gastric cancer; heterogeneity; cellular heterogeneity ... See more keywords
Cellular heterogeneity contributes to subtype-specific expression of ZEB1 in human glioblastoma
Sign Up to like & getrecommendations! Published in 2017 at "PLoS ONE"
DOI: 10.1371/journal.pone.0185376
Abstract: The transcription factor ZEB1 has gained attention in tumor biology of epithelial cancers because of its function in epithelial-mesenchymal transition, DNA repair, stem cell biology and tumor-induced immunosuppression, but its role in gliomas with respect… read more here.
Keywords: zeb1; cellular heterogeneity; expression; biology ... See more keywords
Dissecting Cellular Heterogeneity Using Single-Cell RNA Sequencing
Sign Up to like & getrecommendations! Published in 2019 at "Molecules and Cells"
DOI: 10.14348/molcells.2019.2446
Abstract: Cell-to-cell variability in gene expression exists even in a homogeneous population of cells. Dissecting such cellular heterogeneity within a biological system is a prerequisite for understanding how a biological system is developed, homeo-statically regulated, and… read more here.
Keywords: single cell; cell rna; cellular heterogeneity; dissecting cellular ... See more keywords
Cellular heterogeneity in the 16HBE14o- airway epithelial line impacts biological readouts.
Sign Up to like & getrecommendations! Published in 2023 at "Physiological reports"
DOI: 10.14814/phy2.15700
Abstract: Abstract The airway epithelial cell line, 16HBE14o−, is an important cell model for studying airway disease. 16HBE14o− cells were originally generated from primary human bronchial epithelial cells by SV40‐mediated immortalization, a process that is associated… read more here.
Keywords: 16hbe14o airway; airway epithelial; heterogeneity 16hbe14o; line ... See more keywords
Cellular Heterogeneity and Cooperativity in Glioma Persister Cells Under Temozolomide Treatment
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.835273
Abstract: We have observed a drug-tolerant/persister state in a human glioblastoma (GBM) cell line after exposure to temozolomide, the standard-of-care chemotherapeutic agent for GBM. We used a multicolor lentiviral genetic barcode labeling to follow cell population… read more here.
Keywords: four genes; temozolomide treatment; heterogeneity cooperativity; persister ... See more keywords