Genome-scale CRISPR screening for modifiers of cellular LDL uptake.
Sign Up to like & getrecommendations! Published in 2021 at "PLoS genetics"
DOI: 10.1371/journal.pgen.1009285
Abstract: Hypercholesterolemia is a causal and modifiable risk factor for atherosclerotic cardiovascular disease. A critical pathway regulating cholesterol homeostasis involves the receptor-mediated endocytosis of low-density lipoproteins into hepatocytes, mediated by the LDL receptor. We applied genome-scale… read more here.
Keywords: genome scale; ldl uptake; scale crispr; cellular ldl ... See more keywords