Glutathione Pulse Therapy: Promote Spatiotemporal Delivery of Reduction‐Sensitive Nanoparticles at the “Cellular Level” and Synergize PD‐1 Blockade Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Advanced Science"
DOI: 10.1002/advs.202202744
Abstract: Spatiotemporal delivery of nanoparticles (NPs) at the “cellular level” is critical for nanomedicine, which is expected to deliver as much cytotoxic drug into cancer cells as possible when NPs accumulate in tumors. However, macrophages and… read more here.
Keywords: cellular level; spatiotemporal delivery; therapy; pulse therapy ... See more keywords
Isolation and purification of five phenolic compounds from the Xinjiang wine grape (Vitis Vinifera) and determination of their antioxidant mechanism at cellular level
Sign Up to like & getrecommendations! Published in 2018 at "European Food Research and Technology"
DOI: 10.1007/s00217-018-3070-z
Abstract: Xinjiang wine grapes (Vitis Vinifera) are extraordinarily rich sources of stilbenes. In this study, two pair of isomers of resveratrol dimers trans-ε-viniferin (1) and (+)-cis-ε-viniferin (2), astilbin (4) and isoastilbin (5), and resveratrol tetramer (−)-hopeaphenol… read more here.
Keywords: xinjiang wine; five phenolic; vitis vinifera; phenolic compounds ... See more keywords
Cellular level distributions of Scots pine heartwood and knot heartwood extractives revealed by Raman spectroscopy imaging
Sign Up to like & getrecommendations! Published in 2017 at "Industrial Crops and Products"
DOI: 10.1016/j.indcrop.2017.06.056
Abstract: Abstract Wood extractives are biologically active secondary metabolites that help protect wood and wood products from decay and other forms of biological attack. Despite the influence of distribution on their ability to protect wood, very… read more here.
Keywords: heartwood; scots pine; spectroscopy; cellular level ... See more keywords
Understanding relaxin signalling at the cellular level
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Endocrinology"
DOI: 10.1016/j.mce.2018.12.017
Abstract: The peptide hormone relaxin mediates many biological actions including anti-fibrotic, vasodilatory, angiogenic, anti-inflammatory, anti-apoptotic, and organ protective effects across a range of tissues. At the cellular level, relaxin binds to the G protein-coupled receptor relaxin… read more here.
Keywords: rxfp1; relaxin signalling; understanding relaxin; cellular level ... See more keywords
Why is cancer so common a disease in people yet so rare at a cellular level?
Sign Up to like & getrecommendations! Published in 2020 at "Medical hypotheses"
DOI: 10.1016/j.mehy.2020.110171
Abstract: Cancers are common diseases in people and yet, on a cellular level, are quite rare. The vast majority of both sporadic, spontaneous cancers and inherited germline cancers arise in single foci from singly transformed cells… read more here.
Keywords: cell; people yet; cancer; cellular level ... See more keywords
Nanoparticles Interfere with Chemotaxis: An Example of Nanoparticles as Molecular "Knockouts" at the Cellular Level.
Sign Up to like & getrecommendations! Published in 2021 at "ACS nano"
DOI: 10.1021/acsnano.1c01262
Abstract: Engineered colloidal nanoparticles show great promise in biomedical applications. While much of the work of assessing nanoparticle impact on living systems has been focused on the direct interactions of nanoparticles with cells/organisms, indirect effects via… read more here.
Keywords: nanoparticles interfere; molecular knockouts; interfere chemotaxis; chemotaxis example ... See more keywords
Disruption of Hox9,10,11 function results in cellular level lineage infidelity in the kidney
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-24782-5
Abstract: Hox genes are important regulators of development. The 39 mammalian Hox genes have considerable functional overlap, greatly confounding their study. In this report, we generated mice with multiple combinations of paralogous and flanking Abd-B Hox… read more here.
Keywords: lineage infidelity; lineage; level lineage; function ... See more keywords
Inference of cellular level signaling networks using single‐cell gene expression data in Caenorhabditis elegans reveals mechanisms of cell fate specification
Sign Up to like & getrecommendations! Published in 2017 at "Bioinformatics"
DOI: 10.1093/bioinformatics/btw796
Abstract: Motivation: Cell fate specification plays a key role to generate distinct cell types during metazoan development. However, most of the underlying signaling networks at cellular level are not well understood. Availability of time lapse single‐cell… read more here.
Keywords: cellular level; fate specification; signaling networks; expression ... See more keywords
Sub-cellular level resolution of common genetic variation in the photoreceptor layer identifies continuum between rare disease and common variation
Sign Up to like & getrecommendations! Published in 2022 at "PLOS Genetics"
DOI: 10.1101/2022.03.15.22272407
Abstract: Photoreceptor cells (PRCs) are the light-detecting cells of the retina. Such cells can be non-invasively imaged using optical coherence tomography (OCT) which is used in clinical settings to diagnose and monitor ocular diseases. Here we… read more here.
Keywords: disease; cellular level; variation; common genetic ... See more keywords
Checks and balances at a cellular level
Sign Up to like & getrecommendations! Published in 2018 at "Science"
DOI: 10.1126/science.359.6377.757-e
Abstract: Tissue Homeostasis To stay healthy, tissues must maintain proper ratios of their constituent cell types. Adler et al. developed a framework for describing a range of circuit topologies between two cell types where each secretes… read more here.
Keywords: cell; balances cellular; cell types; checks balances ... See more keywords
Erratum: High-fidelity and rapid cellular-level Mueller matrix imaging for tissue identification with unstained sections: erratum.
Sign Up to like & getrecommendations! Published in 2022 at "Biomedical optics express"
DOI: 10.1364/boe.453181
Abstract: [This corrects the article on p. 4745 in vol. 12, PMID: 34513222.]. read more here.
Keywords: fidelity rapid; high fidelity; rapid cellular; erratum high ... See more keywords