Cellular and metabolic characteristics of pre-leukemic hematopoietic progenitors with GATA2 haploinsuficiency.
Sign Up to like & getrecommendations! Published in 2022 at "Haematologica"
DOI: 10.3324/haematol.2022.279437
Abstract: Mono-Allelic germline disruptions of the transcription factor GATA2 result in a propensity for developing myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML) affecting more than 85% of carriers. How a partial loss of GATA2 functionality… read more here.
Keywords: cellular metabolic; metabolic characteristics; gata2; pre leukemic ... See more keywords
ALS/FTD: Evolution, Aging, and Cellular Metabolic Exhaustion
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DOI: 10.3389/fneur.2022.890203
Abstract: Amyotrophic lateral sclerosis and frontotemporal dementia (ALS/FTD) are neurodegenerations with evolutionary underpinnings, expansive clinical presentations, and multiple genetic risk factors involving a complex network of pathways. This perspective considers the complex cellular pathology of aging… read more here.
Keywords: cellular metabolic; evolution aging; als ftd; aging cellular ... See more keywords
Lactate Activates AMPK Remodeling of the Cellular Metabolic Profile and Promotes the Proliferation and Differentiation of C2C12 Myoblasts
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DOI: 10.3390/ijms232213996
Abstract: Lactate is a general compound fuel serving as the fulcrum of metabolism, which is produced from glycolysis and shuttles between different cells, tissues and organs. Lactate is usually accumulated abundantly in muscles during exercise. It… read more here.
Keywords: cellular metabolic; activates ampk; remodeling cellular; differentiation ... See more keywords