Metabolomics analysis highlights Yashtimadhu (Glycyrrhiza glabra L.)‐mediated neuroprotection in a rotenone‐induced cellular model of Parkinson's disease by restoring the mTORC1‐AMPK1 axis in autophagic regulation
Sign Up to like & getrecommendations! Published in 2022 at "Phytotherapy Research"
DOI: 10.1002/ptr.7449
Abstract: Parkinson's disease (PD) is an age‐associated progressive neurodegenerative movement disorder, and its management strategies are known to cause complications with prolonged usage. We aimed to explore the neuroprotective mechanism of the Indian traditional medicine Yashtimadhu,… read more here.
Keywords: induced cellular; rotenone induced; cellular model; analysis ... See more keywords
MK-801 Treatment of Oligodendrocytes as a Cellular Model of Aging.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-0716-0471-7_32
Abstract: Cardiovascular-related accidents such as stroke are currently ranked as the second leading cause of death worldwide, and the risk of stroke increases dramatically with age. Aging results in structural and functional alterations of the oligodendrocytes… read more here.
Keywords: model aging; cellular model; treatment; 801 treatment ... See more keywords
Dual mTORC1/mTORC2 blocker as a possible therapy for tauopathy in cellular model
Sign Up to like & getrecommendations! Published in 2017 at "Metabolic Brain Disease"
DOI: 10.1007/s11011-017-0137-7
Abstract: Tauopathy comprises a group of disorders caused by abnormal aggregates of tau protein. In these disorders phosphorylated tau protein tends to accumulate inside neuronal cells (soma) instead of the normal axonal distribution of tau. A… read more here.
Keywords: tau; cellular model; blocker; mtor ... See more keywords
Rapid generation of an RBL cellular model to study proteins that cause allergenic reactions in vitro
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DOI: 10.1007/s12026-024-09461-0
Abstract: Allergic diseases affect nearly 30% of people worldwide. There is a wide range of allergen sources, such as animal dander, food, venom, dust mites, and pollen. The skin prick test is the predominant technique used… read more here.
Keywords: generation rbl; rbl; cellular model; rbl cellular ... See more keywords
Epigenetic modification of Nrf2 by sulforaphane increases the antioxidative and anti‐inflammatory capacity in a cellular model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2018.01.046
Abstract: &NA; Sulforaphane was reported to exert neuroprotective effects via upregulating expression of nuclear factor erythroid 2‐related factor 2 (Nrf2) and has received increasing attention as an alternative candidate for treatment of Alzheimer's disease (AD). However,… read more here.
Keywords: alzheimer disease; cellular model; bgr decrease; decrease ... See more keywords
Novel biomolecular information in rotenone-induced cellular model of Parkinson's disease.
Sign Up to like & getrecommendations! Published in 2018 at "Gene"
DOI: 10.1016/j.gene.2018.01.023
Abstract: In order to uncover the remarkable pathogenic genes or molecular pathological process in Parkinson's disease (PD), we employed a microarray analysis upon the cellular PD model induced by rotenone. Compared to the control group, 2174… read more here.
Keywords: process; cellular model; rotenone induced; parkinson disease ... See more keywords
Cytotoxicity and cellular proteome impact of cellulose nanocrystals using simulated digestion and an in vitro small intestinal epithelium cellular model
Sign Up to like & getrecommendations! Published in 2020 at "NanoImpact"
DOI: 10.1016/j.impact.2020.100269
Abstract: Abstract Cellulose nanocrystals (CNC) (0.75 or 1.5% w/w) in either a fasting food model (FFM) or a standardized food model (SFM) based on the average USA diet, were digested using a three-phase (oral-gastric-small intestinal) digestion… read more here.
Keywords: small intestinal; intestinal epithelium; cellular model; model ... See more keywords
Cellular model system to dissect the isoform-selectivity of Akt inhibitors
Sign Up to like & getrecommendations! Published in 2021 at "Nature Communications"
DOI: 10.1038/s41467-021-25512-8
Abstract: The protein kinase Akt plays a pivotal role in cellular processes. However, its isoforms’ distinct functions have not been resolved to date, mainly due to the lack of suitable biochemical and cellular tools. Against this… read more here.
Keywords: akt; cellular model; model system; isoform ... See more keywords
Three-dimensional particle topological cellular model for characterizing seepage channel evolution in large-scale fractured coal
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DOI: 10.1063/5.0291851
Abstract: After coal fragmentation, multi-scale fracture networks develop, where large-scale fractures dominate gas transport within the coal matrix. A three-dimensional particle topological cellular model was established to characterize the flow channel structures within large-scale fractures among… read more here.
Keywords: particle topological; coal; cellular model; model ... See more keywords
In vitro cellular model systems provide a promising alternative to animal experiments for studying the intestine-organ axis
Sign Up to like & getrecommendations! Published in 2025 at "Critical Reviews in Biotechnology"
DOI: 10.1080/07388551.2025.2452620
Abstract: Abstract Limiting animal experiments is essential for ethical issues and also because scientific evidence highlights the discrepancies between human and animal metabolism. This review aims to provide a critical discussion of the strengths and limitations… read more here.
Keywords: model systems; animal experiments; vitro cellular; culture ... See more keywords
Investigating the Therapeutic Mechanism of Cannabidiol in a Human Induced Pluripotent Stem Call (iPSC)-Based Cellular Model of Dravet Syndrome.
Sign Up to like & getrecommendations! Published in 2019 at "Cold Spring Harbor symposia on quantitative biology"
DOI: 10.1101/sqb.2018.83.038174
Abstract: Dravet syndrome is an infantile epileptic encephalopathy primarily caused by loss-of-function variants of the gene SCN1A Standard treatment regimens have very limited efficacy to combat the life-threatening seizures in Dravet syndrome or the behavioral-cognitive comorbidities… read more here.
Keywords: mechanism; model dravet; therapeutic mechanism; cellular model ... See more keywords