Cistanche extracts ameliorates the neurotoxicity induced by hydrogen peroxide in new mutant DJ‐1‐transfected neuroblastoma cellular models
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1304
Abstract: DJ‐1 mutation is a causative reason for familial Parkinson's disease (PD). Leucine166Proline (L166P) and C106S are two important DJ‐1 mutations. In this study, we established hydrogen peroxide (H2O2) induced L166P and C106S DJ‐1‐transfected neuroblastoma (SH‐SY5Y)… read more here.
Keywords: cistanche extracts; hydrogen peroxide; cellular models; extracts ameliorates ... See more keywords
Tissue-engineered multi-cellular models of the uterine wall
Sign Up to like & getrecommendations! Published in 2020 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-020-01296-6
Abstract: The human uterus is composed of three layers: endometrium, myometrium and perimetrium. It remodels during the monthly menstrual cycle and more significantly during the complex stages of reproduction. In vivo studies of the human uterine… read more here.
Keywords: models uterine; uterine wall; cellular models; tissue engineered ... See more keywords
Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00323
Abstract: Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder for which there is no cure or approved treatment. It is characterized by the loss or impaired activity of frataxin protein, which is involved in the biogenesis… read more here.
Keywords: friedreich ataxia; cellular models; oleic acid; analog ... See more keywords
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-017-0020-4
Abstract: Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been implicated in most neurodegenerative diseases, but in many instances it is unclear whether… read more here.
Keywords: models neurodegenerative; dysfunction; neurodegenerative diseases; cellular models ... See more keywords
Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81129-3
Abstract: Patient-derived cellular models become an increasingly powerful tool to model human diseases for precision medicine approaches. The identification of robust cellular disease phenotypes in these models paved the way towards high throughput screenings (HTS) including… read more here.
Keywords: maintenance expansion; expansion; derived cellular; cellular models ... See more keywords
Unraveling the metabolic activities of bioactive compounds on cellular models of hepatosteatosis and adipogenesis through docking analysis with PPARs
Sign Up to like & getrecommendations! Published in 2024 at "Scientific Reports"
DOI: 10.1038/s41598-024-78374-7
Abstract: Obesity is associated with fatty liver disease. Available therapies show modest efficacy, and nutraceuticals with good effectiveness and safety are largely investigated. We focused on five natural compounds, three plant phenolic compounds (carvacrol, rosmarinic acid,… read more here.
Keywords: unraveling metabolic; models hepatosteatosis; hepatosteatosis adipogenesis; cellular models ... See more keywords
Recent advances in cellular models for discovering prion disease therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2113773
Abstract: ABSTRACT Introduction Prion diseases are a group of rare and lethal, rapidly progressive neurodegenerative diseases arising due to conversion of the physiological cellular prion protein into its pathological counterparts, denoted as ‘prions.’ These agents are… read more here.
Keywords: prion; disease; models discovering; advances cellular ... See more keywords
Ex-Vivo 3D Cellular Models of Pancreatic Ductal Adenocarcinoma
Sign Up to like & getrecommendations! Published in 2024 at "Pancreas"
DOI: 10.1097/mpa.0000000000002393
Abstract: Abstract Pancreas is a vital gland of gastrointestinal system with exocrine and endocrine secretory functions, interweaved into essential metabolic circuitries of the human body. Pancreatic ductal adenocarcinoma (PDAC) represents one of the most lethal malignancies,… read more here.
Keywords: ductal adenocarcinoma; cellular models; vivo cellular; models pancreatic ... See more keywords
Lost in HELLS: Disentangling the mystery of SALNR existence in senescence cellular models
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1101/2023.02.03.526712
Abstract: Long non-coding RNAs (lncRNAs) have emerged as key regulators of cellular senescence by transcriptionally and post-transcriptionally modulating the expression of many important genes involved in senescence-associated pathways and processes. Among the different lncRNAs associated to… read more here.
Keywords: existence; mystery; lost hells; senescence ... See more keywords
Advances in common in vitro cellular models of pulmonary fibrosis
Sign Up to like & getrecommendations! Published in 2024 at "Immunology and Cell Biology"
DOI: 10.1111/imcb.12756
Abstract: The development of in vitro models is essential for a comprehensive understanding and investigation of pulmonary fibrosis (PF) at both cellular and molecular levels. This study presents a literature review and an analysis of various… read more here.
Keywords: common vitro; cellular models; advances common; cell ... See more keywords
Amyloid‐β oligomers in cellular models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15030
Abstract: Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to plaque formation, Aβ aggregates into non‐fibrillar soluble oligomers… read more here.
Keywords: alzheimer disease; cellular models; oligomers cellular; amyloid oligomers ... See more keywords