Cistanche extracts ameliorates the neurotoxicity induced by hydrogen peroxide in new mutant DJ‐1‐transfected neuroblastoma cellular models
Sign Up to like & getrecommendations! Published in 2019 at "Brain and Behavior"
DOI: 10.1002/brb3.1304
Abstract: DJ‐1 mutation is a causative reason for familial Parkinson's disease (PD). Leucine166Proline (L166P) and C106S are two important DJ‐1 mutations. In this study, we established hydrogen peroxide (H2O2) induced L166P and C106S DJ‐1‐transfected neuroblastoma (SH‐SY5Y)… read more here.
Keywords: cistanche extracts; hydrogen peroxide; cellular models; extracts ameliorates ... See more keywords
Tissue-engineered multi-cellular models of the uterine wall
Sign Up to like & getrecommendations! Published in 2020 at "Biomechanics and Modeling in Mechanobiology"
DOI: 10.1007/s10237-020-01296-6
Abstract: The human uterus is composed of three layers: endometrium, myometrium and perimetrium. It remodels during the monthly menstrual cycle and more significantly during the complex stages of reproduction. In vivo studies of the human uterine… read more here.
Keywords: models uterine; uterine wall; cellular models; tissue engineered ... See more keywords
Identification of a Novel Oleic Acid Analog with Protective Effects in Multiple Cellular Models of Friedreich Ataxia.
Sign Up to like & getrecommendations! Published in 2020 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.0c00323
Abstract: Friedreich ataxia (FRDA) is an inherited neurodegenerative disorder for which there is no cure or approved treatment. It is characterized by the loss or impaired activity of frataxin protein, which is involved in the biogenesis… read more here.
Keywords: friedreich ataxia; cellular models; oleic acid; analog ... See more keywords
Guidelines on experimental methods to assess mitochondrial dysfunction in cellular models of neurodegenerative diseases
Sign Up to like & getrecommendations! Published in 2017 at "Cell Death and Differentiation"
DOI: 10.1038/s41418-017-0020-4
Abstract: Neurodegenerative diseases are a spectrum of chronic, debilitating disorders characterised by the progressive degeneration and death of neurons. Mitochondrial dysfunction has been implicated in most neurodegenerative diseases, but in many instances it is unclear whether… read more here.
Keywords: models neurodegenerative; dysfunction; neurodegenerative diseases; cellular models ... See more keywords
Integrated, automated maintenance, expansion and differentiation of 2D and 3D patient-derived cellular models for high throughput drug screening
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-81129-3
Abstract: Patient-derived cellular models become an increasingly powerful tool to model human diseases for precision medicine approaches. The identification of robust cellular disease phenotypes in these models paved the way towards high throughput screenings (HTS) including… read more here.
Keywords: maintenance expansion; expansion; derived cellular; cellular models ... See more keywords
Recent advances in cellular models for discovering prion disease therapeutics
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Drug Discovery"
DOI: 10.1080/17460441.2022.2113773
Abstract: ABSTRACT Introduction Prion diseases are a group of rare and lethal, rapidly progressive neurodegenerative diseases arising due to conversion of the physiological cellular prion protein into its pathological counterparts, denoted as ‘prions.’ These agents are… read more here.
Keywords: prion; disease; models discovering; advances cellular ... See more keywords
Lost in HELLS: Disentangling the mystery of SALNR existence in senescence cellular models
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1101/2023.02.03.526712
Abstract: Long non-coding RNAs (lncRNAs) have emerged as key regulators of cellular senescence by transcriptionally and post-transcriptionally modulating the expression of many important genes involved in senescence-associated pathways and processes. Among the different lncRNAs associated to… read more here.
Keywords: existence; mystery; lost hells; senescence ... See more keywords
Amyloid‐β oligomers in cellular models of Alzheimer’s disease
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Neurochemistry"
DOI: 10.1111/jnc.15030
Abstract: Amyloid‐β (Aβ) dysmetabolism is tightly associated with pathological processes in Alzheimer's disease (AD). Currently, it is thought that, in addition to Aβ fibrils that give rise to plaque formation, Aβ aggregates into non‐fibrillar soluble oligomers… read more here.
Keywords: alzheimer disease; cellular models; oligomers cellular; amyloid oligomers ... See more keywords
Patient-derived cellular models of primary ciliopathies
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Medical Genetics"
DOI: 10.1136/jmedgenet-2021-108315
Abstract: Primary ciliopathies are rare inherited disorders caused by structural or functional defects in the primary cilium, a subcellular organelle present on the surface of most cells. Primary ciliopathies show considerable clinical and genetic heterogeneity, with… read more here.
Keywords: derived cellular; models primary; patient derived; primary ciliopathies ... See more keywords
Genomic, Transcriptomic, and Proteomic Depiction of Induced Pluripotent Stem Cells–Derived Smooth Muscle Cells As Emerging Cellular Models for Arterial Diseases
Sign Up to like & getrecommendations! Published in 2023 at "Hypertension"
DOI: 10.1161/hypertensionaha.122.19733
Abstract: Background: Vascular smooth muscle cells (SMCs) plasticity is a central mechanism in cardiovascular health and disease. We aimed at providing cellular phenotyping, epigenomic and proteomic depiction of SMCs derived from induced pluripotent stem cells and… read more here.
Keywords: pluripotent stem; smcs; induced pluripotent; smooth muscle ... See more keywords
Influence of cellular models and individual factor in the biological response to chest CT scan exams
Sign Up to like & getrecommendations! Published in 2022 at "European Radiology Experimental"
DOI: 10.1186/s41747-022-00266-0
Abstract: Background While computed tomography (CT) exams are the major cause of medical exposure to ionising radiation, there is increasing evidence that the potential radiation-induced risks must be documented. We investigated the impact of cellular models… read more here.
Keywords: individual factor; cellular models; biological response; chest scan ... See more keywords