Restoring cellular NAD(P)H levels by PPARα and LXRα stimulation to improve mitochondrial complex I deficiency.
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DOI: 10.1016/j.lfs.2022.120571
Abstract: Mitochondrial complex I (CI), the first multiprotein enzyme complex of the oxidative phosphorylation system, plays a crucial role in cellular energy production. CI deficiency is associated with a variety of clinical phenotypes, including Leigh syndrome.… read more here.
Keywords: deficiency; nad levels; nad; cellular nad ... See more keywords