Development of a novel reporter gene assay to evaluate antibody-dependent cellular phagocytosis for anti-CD20 therapeutic antibodies.
Sign Up to like & getrecommendations! Published in 2021 at "International immunopharmacology"
DOI: 10.1016/j.intimp.2021.108112
Abstract: More than 100 monoclonal antibodies (mAbs) have been approved by FDA. The mechanism of action (MoA) involves in neutralization of a specific target via the Fab region and Fc effector functions through Fc region, while… read more here.
Keywords: antibody; adcp; cellular phagocytosis; antibody dependent ... See more keywords
CLEC5a-directed bispecific antibody for effective cellular phagocytosis
Sign Up to like & getrecommendations! Published in 2022 at "mAbs"
DOI: 10.1080/19420862.2022.2040083
Abstract: ABSTRACT While antibody-dependent cellular phagocytosis mediated by activating Fcγ receptor is a key mechanism underlying many antibody drugs, their full therapeutic activities can be restricted by the inhibitory Fcγ receptor IIB (FcγRIIB). Here, we describe… read more here.
Keywords: bispecific antibody; cellular phagocytosis; clec5a; phagocytosis ... See more keywords