Dynamic Transcriptional and Epigenetic Changes Drive Cellular Plasticity in the Liver
Sign Up to like & getrecommendations! Published in 2021 at "Hepatology"
DOI: 10.1002/hep.31704
Abstract: Following liver injury, a fraction of hepatocytes adopt features of biliary epithelial cells (BECs) in a process known as biliary reprogramming. The aim of this study was to elucidate the molecular events accompanying this dramatic… read more here.
Keywords: dynamic transcriptional; cellular plasticity; changes drive; epigenetic changes ... See more keywords
The epigenetic basis of cellular plasticity.
Sign Up to like & getrecommendations! Published in 2017 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.01.003
Abstract: Cellular plasticity is now recognized as a fundamental feature of tissue biology. The steady-state differentiation of stem and progenitor cells into mature cells is, in itself, the index form of cellular plasticity in adult organisms.… read more here.
Keywords: basis cellular; cellular plasticity; epigenetic basis; biology ... See more keywords
Cellular Plasticity in Intestinal Homeostasis and Disease.
Sign Up to like & getrecommendations! Published in 2019 at "Cell stem cell"
DOI: 10.1016/j.stem.2018.11.019
Abstract: The intestinal epithelium is one the fastest renewing tissues in mammals and is endowed with extensive adaptability. The more traditional view of a hierarchical organization of the gut has recently given way to a more… read more here.
Keywords: homeostasis disease; plasticity intestinal; cellular plasticity; intestinal homeostasis ... See more keywords
Radiation-induced cellular plasticity primes glioblastoma for forskolin-mediated differentiation
Sign Up to like & getrecommendations! Published in 2025 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2415557122
Abstract: Significance The distinctive nature of glioblastoma (GBM) and the blood–brain barrier (BBB) are obstacles for therapies that aim to permanently stop glioma cells from dividing. Similar to reprogramming normal cells, “differentiation therapies” try to push… read more here.
Keywords: differentiation; induced cellular; radiation; radiation induced ... See more keywords
STEM-20. MULTI-OMICS OF HUMAN MEDULLOBLASTOMAS AND GENETIC LINEAGE TRACING IN VIVO INDICATE CELLULAR PLASTICITY
Sign Up to like & getrecommendations! Published in 2024 at "Neuro-Oncology"
DOI: 10.1093/neuonc/noae165.0246
Abstract: Recent single-cell studies implicate the glutamatergic lineage of the rhombic lip (RL) as the origin of group (G) 3/4 medulloblastomas (MBs) and a stalled differentiation program as underlying malignant transformation. While the cellular compositions of… read more here.
Keywords: cellular plasticity; cell; genetic lineage; single cell ... See more keywords
Cellular Plasticity in Response to Suppression of Storage Proteins in the Brassica napus Embryo[OPEN]
Sign Up to like & getrecommendations! Published in 2020 at "Plant Cell"
DOI: 10.1105/tpc.19.00879
Abstract: Suppressing the genes encoding napin and cruciferin leads to an increase in oleosin accumulation and a reorganization of the intracellular architecture in the developing embryo of oilseed rape. The tradeoff between protein and oil storage… read more here.
Keywords: protein; storage; suppression storage; cellular plasticity ... See more keywords
Abstract SY26-01: Mapping cellular plasticity in tumor progression and drug resistance
Sign Up to like & getrecommendations! Published in 2023 at "Cancer Research"
DOI: 10.1158/1538-7445.am2023-sy26-01
Abstract: Cellular plasticity is emerging as an important driving force underlying cancer progression and drug resistance. In this talk, I will discuss the concept of cancer cell states present in the tumor prior to treatment, as… read more here.
Keywords: cancer; progression drug; resistance; cellular plasticity ... See more keywords
Abstract 1179: Epigenetic subtypes and cellular plasticity are driven by an interplay between RUNX2 and FOSL1 in osteosarcoma
Sign Up to like & getrecommendations! Published in 2025 at "Cancer Research"
DOI: 10.1158/1538-7445.am2025-1179
Abstract: Chromatin accessibility is a crucial driver of cellular plasticity, priming gene expression and defining distinct cellular states. Variability in chromatin accessibility is a significant determinant of epigenetic transcriptional regulation and can reveal clinically relevant subtypes… read more here.
Keywords: runx2 fosl1; osteosarcoma; plasticity; cellular plasticity ... See more keywords
Developmental Plasticity and Cellular Reprogramming in Caenorhabditis elegans
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302333
Abstract: While Caenorhabditis elegans was originally regarded as a model for investigating determinate developmental programs, landmark studies have subsequently shown that the largely invariant pattern of development in the animal does not reflect irreversibility in rigidly… read more here.
Keywords: developmental plasticity; cellular plasticity; caenorhabditis elegans; plasticity ... See more keywords
Dynamics of Cellular Plasticity in Prostate Cancer Progression
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2020.00130
Abstract: Despite the current advances in the treatment for prostate cancer, the patients often develop resistance to the conventional therapeutic interventions. Therapy-induced drug resistance and tumor progression have been associated with cellular plasticity acquired due to… read more here.
Keywords: cellular plasticity; prostate cancer; cancer; progression ... See more keywords
Evolutionary conservation of dopamine-mediated cellular plasticity in Arctic sponges (Porifera)
Sign Up to like & getrecommendations! Published in 2025 at "Frontiers in Molecular Biosciences"
DOI: 10.3389/fmolb.2025.1671771
Abstract: Dopamine is an evolutionarily ancient signaling molecule implicated in stress responses across the tree of life. The role of dopamine is well-documented in the nervous system of animals, yet in the early-branching animal lineage of… read more here.
Keywords: dopamine; conservation dopamine; dopamine mediated; plasticity ... See more keywords