Rescue of Transgenic Alzheimer's Pathophysiology by Polymeric Cellular Prion Protein Antagonists.
Sign Up to like & getrecommendations! Published in 2019 at "Cell reports"
DOI: 10.1016/j.celrep.2018.12.021
Abstract: Cellular prion protein (PrPC) binds the scrapie conformation of PrP (PrPSc) and oligomeric β-amyloid peptide (Aβo) to mediate transmissible spongiform encephalopathy (TSE) and Alzheimer's disease (AD), respectively. We conducted cellular and biochemical screens for compounds… read more here.
Keywords: pathophysiology; alzheimer; prion protein; cellular prion ... See more keywords
Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2209815120
Abstract: Significance In the fatal brain disorders known as prion diseases, the cellular prion protein (PrPC) is converted into an abnormal structure by other abnormal prion protein molecules. A fragmentation process known as β-cleavage that splits… read more here.
Keywords: prion; dipeptidyl peptidase; prion protein; cellular prion ... See more keywords
Sleep inhibition induced by amyloid‐β oligomers is mediated by the cellular prion protein
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Sleep Research"
DOI: 10.1111/jsr.13187
Abstract: Sleep is severely impaired in patients with Alzheimer's disease. Amyloid‐β deposition in the brain of Alzheimer's disease patients is a key event in its pathogenesis and is associated with disrupted sleep, even before the appearance… read more here.
Keywords: amyloid oligomers; mediated cellular; prion protein; cellular prion ... See more keywords
The biological function of the cellular prion protein: an update
Sign Up to like & getrecommendations! Published in 2017 at "BMC Biology"
DOI: 10.1186/s12915-017-0375-5
Abstract: The misfolding of the cellular prion protein (PrPC) causes fatal neurodegenerative diseases. Yet PrPC is highly conserved in mammals, suggesting that it exerts beneficial functions preventing its evolutionary elimination. Ablation of PrPC in mice results… read more here.
Keywords: biological function; prion protein; function cellular; cellular prion ... See more keywords
Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Brain"
DOI: 10.1186/s13041-018-0406-3
Abstract: N-Methyl-D-aspartate receptors (NMDARs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors (AMPARs) are two major types of ionotropic glutamate receptors involved in synaptic transmission. However, excessive activity of these receptors can be cytotoxic and thus their function must be… read more here.
Keywords: cellular prion; copper; prion protein; copper ions ... See more keywords
Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein
Sign Up to like & getrecommendations! Published in 2022 at "PLoS ONE"
DOI: 10.1371/journal.pone.0270915
Abstract: It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrPC) can prolong survival in a group of neurodegenerative diseases known as prion diseases. To date, efforts to decrease steady-state… read more here.
Keywords: prion; cellular prion; prion protein; levels cellular ... See more keywords
Involvement of Cellular Prion Protein in Invasion and Metastasis of Lung Cancer by Inducing Treg Cell Development
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11020285
Abstract: The cellular prion protein (PrPC) is a cell surface glycoprotein expressed in many cell types that plays an important role in normal cellular processes. However, an increase in PrPC expression has been associated with a… read more here.
Keywords: cancer; cellular prion; cell; invasion metastasis ... See more keywords
The Effects of Fibrinogen’s Interactions with Its Neuronal Receptors, Intercellular Adhesion Molecule-1 and Cellular Prion Protein
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11091381
Abstract: Neuroinflammatory diseases, such as Alzheimer’s disease (AD) and traumatic brain injury (TBI), are associated with the extravascular deposition of the fibrinogen (Fg) derivative fibrin and are accompanied with memory impairment. We found that during the… read more here.
Keywords: cellular prion; neuronal receptors; adhesion molecule; prion protein ... See more keywords
Identification of a Cardiac Glycoside Exhibiting Favorable Brain Bioavailability and Potency for Reducing Levels of the Cellular Prion Protein
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232314823
Abstract: Several strands of investigation have established that a reduction in the levels of the cellular prion protein (PrPC) is a promising avenue for the treatment of prion diseases. We recently described an indirect approach for… read more here.
Keywords: prion; cellular prion; prion protein; brain ... See more keywords
Pharmacological Agents Targeting the Cellular Prion Protein
Sign Up to like & getrecommendations! Published in 2018 at "Pathogens"
DOI: 10.3390/pathogens7010027
Abstract: Prion diseases are associated with the conversion of the cellular prion protein (PrPC), a glycoprotein expressed at the surface of a wide variety of cell types, into a misfolded conformer (the scrapie form of PrP,… read more here.
Keywords: prpc; cellular prion; pharmacological agents; prion ... See more keywords