Promiscuous Targeting of Cellular Proteins by Vpr Drives Systems-Level Proteomic Remodeling in HIV-1 Infection
Sign Up to like & getrecommendations! Published in 2019 at "Cell Reports"
DOI: 10.1016/j.celrep.2019.04.025
Abstract: Summary HIV-1 encodes four “accessory proteins” (Vif, Vpr, Vpu, and Nef), dispensable for viral replication in vitro but essential for viral pathogenesis in vivo. Well characterized cellular targets have been associated with Vif, Vpu, and… read more here.
Keywords: promiscuous targeting; proteins vpr; targeting cellular; cellular proteins ... See more keywords
Highly multiplexed single-cell RNA-seq by DNA oligonucleotide tagging of cellular proteins
Sign Up to like & getrecommendations! Published in 2019 at "Nature Biotechnology"
DOI: 10.1038/s41587-019-0372-z
Abstract: We describe a universal sample multiplexing method for single-cell RNA sequencing in which fixed cells are chemically labeled by attaching identifying DNA oligonucleotides to cellular proteins. Analysis of a 96-plex perturbation experiment revealed changes in… read more here.
Keywords: single cell; dna; cell rna; cellular proteins ... See more keywords
A tissue-to-organelle view of cellular proteins
Sign Up to like & getrecommendations! Published in 2018 at "Nature Methods"
DOI: 10.1038/s41592-018-0163-3
Abstract: By coupling multiplex iterative indirect immunofluorescence imaging with computer vision methods, researchers can detect at least 40 different proteins with subcellular resolution. read more here.
Keywords: tissue organelle; cellular proteins; view cellular; organelle view ... See more keywords
Two structural switches in HIV-1 capsid regulate capsid curvature and host factor binding
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1101/2022.12.02.518879
Abstract: The mature HIV-1 capsid protects the viral genome and interacts with host proteins to travel from the cell periphery into the nucleus. To achieve this, the capsid protein, CA, constructs conical capsids from a lattice… read more here.
Keywords: two structural; hiv capsid; curvature; capsid ... See more keywords
Interferon Alpha Induces Multiple Cellular Proteins That Coordinately Suppress Hepadnaviral Covalently Closed Circular DNA Transcription
Sign Up to like & getrecommendations! Published in 2020 at "Journal of Virology"
DOI: 10.1128/jvi.00442-20
Abstract: Pegylated IFN-α is the only therapeutic regimen that can induce a functional cure of chronic hepatitis B in a small, but significant, fraction of treated patients. Understanding the mechanisms underlying the antiviral functions of IFN-α… read more here.
Keywords: cccdna; cccdna transcription; stat1 smchd1; transcription ... See more keywords
Novel role of HIV-1 Nef in regulating the ubiquitination of cellular proteins
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cellular and Infection Microbiology"
DOI: 10.3389/fcimb.2023.1106591
Abstract: Our recent data established that HIV-1 Nef is pivotal in determining the fate of cellular proteins by modulating ubiquitination. However, it is unknown which proteins are ubiquitinated in the presence of Nef, a question critical… read more here.
Keywords: novel role; hiv nef; analysis; cellular proteins ... See more keywords
Liaisons dangereuses: Intrinsic Disorder in Cellular Proteins Recruited to Viral Infection-Related Biocondensates
Sign Up to like & getrecommendations! Published in 2023 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24032151
Abstract: Liquid–liquid phase separation (LLPS) is responsible for the formation of so-called membrane-less organelles (MLOs) that are essential for the spatio-temporal organization of the cell. Intrinsically disordered proteins (IDPs) or regions (IDRs), either alone or in… read more here.
Keywords: viral infection; infection related; cellular proteins; disorder content ... See more keywords
Identifying Endogenous Cellular Proteins Destabilizing the Propagation of Swi1 Prion upon Overproduction
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14071366
Abstract: (1) Background: Numerous prions exist in the budding yeast, including [SWI+], the prion form of Swi1—a subunit of the chromatin-remodeling complex SWI/SNF. Despite decades of research, the molecular mechanisms underlying prion initiation and propagation are… read more here.
Keywords: prion; upon overproduction; swi suppressors; swi1 ... See more keywords
Shuttling of cellular proteins between the plasma membrane and nucleus
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Medicine Reports"
DOI: 10.3892/mmr.2021.12530
Abstract: Recently accumulated evidence has indicated that the nucleomembrane shuttling of cellular proteins is common, which provides new insight into the subcellular translocation and biological functions of proteins synthesized in the cytoplasm. The present study aimed… read more here.
Keywords: membrane nucleus; proteins plasma; shuttling cellular; cellular proteins ... See more keywords