Cellular Proteostasis in Neurodegeneration
Sign Up to like & getrecommendations! Published in 2018 at "Molecular Neurobiology"
DOI: 10.1007/s12035-018-1334-z
Abstract: The term proteostasis reflects the fine-tuned balance of cellular protein levels, mediated through a vast network of biochemical pathways. This requires the regulated control of protein folding, post-translational modification, and protein degradation. Due to the… read more here.
Keywords: protein; cellular proteostasis; proteostasis; neurodegenerative diseases ... See more keywords
Cellular proteostasis: a new twist in the action of thymosin α1
Sign Up to like & getrecommendations! Published in 2018 at "Expert Opinion on Biological Therapy"
DOI: 10.1080/14712598.2018.1484103
Abstract: ABSTRACT Introduction: Thymosin alpha 1 (Tα1) is a naturally occurring polypeptide of 28 amino acids, whose mechanism of action is thought to be related to its ability to signal through innate immune receptors. Tα1 (ZADAXIN®)… read more here.
Keywords: new twist; cellular proteostasis; proteostasis new; thymosin ... See more keywords
Linking cellular proteostasis to yeast longevity
Sign Up to like & getrecommendations! Published in 2018 at "FEMS Yeast Research"
DOI: 10.1093/femsyr/foy043
Abstract: Proteostasis is a cellular housekeeping process that refers to the healthy maintenance of the cellular proteome that governs the fate of proteins from synthesis to degradation. Perturbations of proteostasis might result in protein dysfunction with… read more here.
Keywords: proteostasis yeast; cellular proteostasis; network; proteostasis ... See more keywords
Understanding and exploiting interactions between cellular proteostasis pathways and infectious prion proteins for therapeutic benefit
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DOI: 10.1098/rsob.200282
Abstract: Several neurodegenerative diseases of humans and animals are caused by the misfolded prion protein (PrPSc), a self-propagating protein infectious agent that aggregates into oligomeric, fibrillar structures and leads to cell death by incompletely understood mechanisms.… read more here.
Keywords: cellular proteostasis; interactions cellular; exploiting interactions; prion ... See more keywords