The expanding horizon of MicroRNAs in cellular reprogramming
Sign Up to like & getrecommendations! Published in 2017 at "Progress in Neurobiology"
DOI: 10.1016/j.pneurobio.2016.11.003
Abstract: &NA; Research over the last few years in cellular reprogramming has enlightened the magical potential of microRNAs (miRNAs) in changing the cell fate from somatic to pluripotent. Recent investigations on exploring the role(s) of miRNAs… read more here.
Keywords: role mirnas; horizon micrornas; expanding horizon; cell ... See more keywords
Cellular Reprogramming as a Therapeutic Target in Cancer.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2019.05.001
Abstract: Cancer heterogeneity has long been recognized as an important clinical determinant of patient outcomes and, thus, many new cancer treatments have been designed to target these different cells. Despite the short-term achievements of current therapies,… read more here.
Keywords: target cancer; biology; reprogramming therapeutic; cancer ... See more keywords
USP26 functions as a negative regulator of cellular reprogramming by stabilising PRC1 complex components
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00301-4
Abstract: Despite much progress in the comprehension of the complex process of somatic cell reprogramming, many questions regarding the molecular mechanism of regulation remain to be answered. At present, the knowledge on the negative regulation of… read more here.
Keywords: negative regulator; cbx4 cbx6; usp26 functions; functions negative ... See more keywords
Cellular reprogramming dynamics follow a simple 1D reaction coordinate.
Sign Up to like & getrecommendations! Published in 2017 at "Physical biology"
DOI: 10.1088/1478-3975/aa90e0
Abstract: Cellular reprogramming, the conversion of one cell type to another, induces global changes in gene expression involving thousands of genes, and understanding how cells globally alter their gene expression profile during reprogramming is an ongoing… read more here.
Keywords: reaction coordinate; cellular reprogramming; gene expression;
A Comparative Approach of Cellular Reprogramming in the Rodentia Order.
Sign Up to like & getrecommendations! Published in 2020 at "Cellular reprogramming"
DOI: 10.1089/cell.2020.0024
Abstract: Cellular reprogramming mainly involves induction of reactivation of genes responsible for nuclear plasticity, a process that can be performed in vitro through production of cloned embryos by somatic cell nuclear transfer or by induction of… read more here.
Keywords: comparative approach; approach cellular; cellular reprogramming; rodentia order ... See more keywords
Intermediate cells of in vitro cellular reprogramming and in vivo tissue regeneration require desmoplakin
Sign Up to like & getrecommendations! Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abk1239
Abstract: Amphibians and fish show considerable regeneration potential via dedifferentiation of somatic cells into blastemal cells. In terms of dedifferentiation, in vitro cellular reprogramming has been proposed to share common processes with in vivo tissue regeneration,… read more here.
Keywords: regeneration; cellular reprogramming; intermediate cells; vitro cellular ... See more keywords
Corrigendum: Potentials of Cellular Reprogramming as a Novel Strategy for Neuroregeneration
Sign Up to like & getrecommendations! Published in 2019 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2019.00147
Abstract: [This corrects the article DOI: 10.3389/fncel.2018.00460.]. read more here.
Keywords: corrigendum potentials; potentials cellular; reprogramming novel; strategy neuroregeneration ... See more keywords
Cellular Reprogramming and Its Potential Application in Alzheimer’s Disease
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2022.884667
Abstract: Alzheimer’s disease (AD) has become the most common age-related dementia in the world and is currently incurable. Although many efforts have been made, the underlying mechanisms of AD remain unclear. Extracellular amyloid-beta deposition, intracellular tau… read more here.
Keywords: reprogramming potential; cellular reprogramming; potential application; alzheimer disease ... See more keywords
Cell Reprogramming for Regeneration and Repair of the Nervous System
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10102598
Abstract: A persistent barrier to the cure and treatment of neurological diseases is the limited ability of the central and peripheral nervous systems to undergo neuroregeneration and repair. Recent efforts have turned to regeneration of various… read more here.
Keywords: cell reprogramming; regeneration; cell; cellular reprogramming ... See more keywords