Viral infections in humans and mice with genetic deficiencies of the type I IFN response pathway
Sign Up to like & getrecommendations! Published in 2021 at "European Journal of Immunology"
DOI: 10.1002/eji.202048793
Abstract: Type I IFNs are so‐named because they interfere with viral infection in vertebrate cells. The study of cellular responses to type I IFNs led to the discovery of the JAK‐STAT signaling pathway, which also governs… read more here.
Keywords: response; cellular responses; viral infections; ifns ... See more keywords
Two-photon excited fluorescence (TPEF) may be useful to identify macrophage subsets based on their metabolic activity and cellular responses in atherosclerotic plaques.
Sign Up to like & getrecommendations! Published in 2020 at "Atherosclerosis"
DOI: 10.1016/j.atherosclerosis.2020.07.017
Abstract: BACKGROUND AND AIMS Atherosclerosis is characterized by the formation of lipid plaques within the arterial wall. In such plaques, the massive and continuous recruitment of circulating monocyte-derived macrophages induces inflammation, leading to plaque destabilization and… read more here.
Keywords: atherosclerotic plaques; cellular responses; metabolic activity; macrophage ... See more keywords
A Library of Phosphoproteomic and Chromatin Signatures for Characterizing Cellular Responses to Drug Perturbations
Sign Up to like & getrecommendations! Published in 2018 at "Cell systems"
DOI: 10.1016/j.cels.2018.03.012
Abstract: SUMMARY Although the value of proteomics has been demonstrated, cost and scale are typically prohibitive, and gene expression profiling remains dominant for characterizing cellular responses to perturbations. However, high-throughput sentinel assays provide an opportunity for… read more here.
Keywords: characterizing cellular; cellular responses; chromatin signatures; signatures characterizing ... See more keywords
Imaging cellular responses to antigen tagged DNA damage.
Sign Up to like & getrecommendations! Published in 2018 at "DNA repair"
DOI: 10.1016/j.dnarep.2018.08.023
Abstract: Repair pathways of covalent DNA damage are understood in considerable detail due to decades of brilliant biochemical studies by many investigators. An important feature of these experiments is the defined adduct location on oligonucleotide or… read more here.
Keywords: dna damage; responses antigen; cellular responses; imaging cellular ... See more keywords
Exploring the Impact of In Vitro-Transcribed mRNA Impurities on Cellular Responses
Sign Up to like & getrecommendations! Published in 2024 at "Analytical Chemistry"
DOI: 10.1021/acs.analchem.4c04162
Abstract: Advances in mRNA technology have enabled mRNA-based therapies to enter a new era of medicine. Such therapies benefit from a single, standardized in vitro transcription (IVT) manufacturing process applicable to a wide range of targets.… read more here.
Keywords: impact vitro; cellular responses; exploring impact; vitro transcribed ... See more keywords
3D Printed Ti–6Al–4V Implant with a Micro/Nanostructured Surface and Its Cellular Responses
Sign Up to like & getrecommendations! Published in 2020 at "ACS Omega"
DOI: 10.1021/acsomega.0c04373
Abstract: Three-dimensional (3D) printing technology has been proved to be a powerful tool for the free-form fabrication of titanium (Ti) implants. However, the surface quality of 3D printed Ti implants is not suitable for clinical application… read more here.
Keywords: cellular responses; microscopy; micro nanostructured; surface ... See more keywords
Interplay between ADP-ribosyltransferases and essential cell signaling pathways controls cellular responses
Sign Up to like & getrecommendations! Published in 2021 at "Cell Discovery"
DOI: 10.1038/s41421-021-00323-9
Abstract: Signaling cascades provide integrative and interactive frameworks that allow the cell to respond to signals from its environment and/or from within the cell itself. The dynamic regulation of mammalian cell signaling pathways is often modulated… read more here.
Keywords: adp ribosyltransferases; signaling pathways; cellular responses; adp ribosylation ... See more keywords
Multi-input chemical control of protein dimerization for programming graded cellular responses
Sign Up to like & getrecommendations! Published in 2019 at "Nature biotechnology"
DOI: 10.1038/s41587-019-0242-8
Abstract: Chemical and optogenetic methods for post-translationally controlling protein function have enabled modulation and engineering of cellular functions. However, most of these methods only confer single-input, single-output control. To increase the diversity of post-translational behaviors that… read more here.
Keywords: protein; cellular responses; dimerization; control ... See more keywords
Longitudinal analysis of humoral and cellular immunity in SARS-CoV-2 exposed families
Sign Up to like & getrecommendations! Published in 2025 at "Scientific Reports"
DOI: 10.1038/s41598-025-07739-3
Abstract: Identification of previous SARS-CoV-2 infection typically relies on serology, yet T-cells play a key role in the adaptive immune response against SARS-CoV-2. Here, we investigated in parallel the SARS-CoV-2-specific as well as endemic human coronavirus-specific… read more here.
Keywords: sars cov; analysis; response; cellular responses ... See more keywords
Correlation of single-cell ICP-MS intensity distributions for the study of heterogeneous cellular responses to environmental stresses
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Analytical Atomic Spectrometry"
DOI: 10.1039/c6ja00348f
Abstract: Biological cells in a population can behave heterogeneously upon uniform external stimulation, i.e., responses of subpopulations of the cells are different. Therefore, distributions of cell properties, rather than the average, are more meaningful for the… read more here.
Keywords: single cell; cellular responses; intensity; correlation ... See more keywords
An array-based nanosensor for detecting cellular responses in macrophages induced by femtomolar levels of pesticides.
Sign Up to like & getrecommendations! Published in 2022 at "Chemical communications"
DOI: 10.1039/d1cc07100a
Abstract: Environmental agents can induce cellular responses at concentrations far below the limits of detection for current viability and biomarker-based cell sensing platforms. Hypothesis-free cell sensor platforms can be engineered to maximize sensitivity to phenotypic changes,… read more here.
Keywords: detecting cellular; responses macrophages; based nanosensor; array based ... See more keywords