microRNA‐99a‐5p induces cellular senescence in gemcitabine‐resistant bladder cancer by targeting SMARCD1
Sign Up to like & getrecommendations! Published in 2022 at "Molecular Oncology"
DOI: 10.1002/1878-0261.13192
Abstract: Patients with advanced bladder cancer are generally treated with a combination of chemotherapeutics, including gemcitabine, but the effect is limited due to acquisition of drug resistance. Thus, in this study, we investigated the mechanism of… read more here.
Keywords: cellular senescence; gemcitabine; gemcitabine resistant; bladder cancer ... See more keywords
Recent Advances in Strategies for Imaging Detection and Intervention of Cellular Senescence
Sign Up to like & getrecommendations! Published in 2022 at "ChemBioChem"
DOI: 10.1002/cbic.202200364
Abstract: Cellular senescence is a stable cell cycle arrest state that can be triggered by a wide range of intrinsic or extrinsic stresses. Increased burden of senescent cells in various tissues is thought to contribute to… read more here.
Keywords: advances strategies; senescence; detection; senescent cells ... See more keywords
Cellular senescence: Silent operator and therapeutic target in cancer
Sign Up to like & getrecommendations! Published in 2021 at "IUBMB Life"
DOI: 10.1002/iub.2460
Abstract: The process of carcinogenesis and its progression involves an intricate interplay between a number of signaling networks, metabolic pathways and the microenvironment. These include an alteration in the cellular redox metabolism and deregulation of cell… read more here.
Keywords: silent operator; senescence; cellular senescence; cancer ... See more keywords
Bone Marrow Adiposity in Models of Radiation‐ and Aging‐Related Bone Loss Is Dependent on Cellular Senescence
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bone and Mineral Research"
DOI: 10.1002/jbmr.4537
Abstract: Oxidative stress‐induced reactive oxygen species, DNA damage, apoptosis, and cellular senescence have been associated with reduced osteoprogenitors in a reciprocal fashion to bone marrow adipocyte tissue (BMAT); however, a direct (causal) link between cellular senescence… read more here.
Keywords: bone marrow; bone; bmat; bone loss ... See more keywords
The Importance of Cellular Senescence in Frailty and Cardiovascular Diseases.
Sign Up to like & getrecommendations! Published in 2020 at "Advances in experimental medicine and biology"
DOI: 10.1007/978-3-030-33330-0_9
Abstract: Frailty is a complex clinical syndrome, progressively described in the last thirty years, resulting from multiple impairments across many organs and systems and characterized by a reduction in physiological reserves and increased vulnerability to stressors,… read more here.
Keywords: age related; senescence; cardiovascular diseases; frailty ... See more keywords
Wogonin induces cellular senescence in breast cancer via suppressing TXNRD2 expression
Sign Up to like & getrecommendations! Published in 2020 at "Archives of Toxicology"
DOI: 10.1007/s00204-020-02842-y
Abstract: Cellular senescence contributes to tumor regression through both cell autonomous and non-autonomous mechanisms. Drugs inducing cancer cell senescence and modulating senescence-associated secretory phenotype (SASP) render advantage to the cancer treatment. Breast cancer remains the second… read more here.
Keywords: senescence; breast cancer; cellular senescence; cancer ... See more keywords
Cellular senescence in the cholangiopathies: a driver of immunopathology and a novel therapeutic target.
Sign Up to like & getrecommendations! Published in 2022 at "Seminars in immunopathology"
DOI: 10.1007/s00281-022-00909-9
Abstract: The cholangiopathies are a group of liver diseases that affect cholangiocytes, the epithelial cells that line the bile ducts. Biliary atresia (BA), primary biliary cholangitis (PBC), and primary sclerosing cholangitis (PSC) are three cholangiopathies with… read more here.
Keywords: cellular senescence; pbc psc; immunopathology; cholangiocyte senescence ... See more keywords
Obesity and type-2 diabetes as inducers of premature cellular senescence and ageing
Sign Up to like & getrecommendations! Published in 2018 at "Biogerontology"
DOI: 10.1007/s10522-018-9763-7
Abstract: Cellular senescence is now considered as a major mechanism in the development and progression of various diseases and this may include metabolic diseases such as obesity and type-2 diabetes. The presence of obesity and diabetes… read more here.
Keywords: obesity type; senescence; disease; type diabetes ... See more keywords
Perspectives on the dynamic implications of cellular senescence and immunosenescence on macrophage aging biology.
Sign Up to like & getrecommendations! Published in 2021 at "Biogerontology"
DOI: 10.1007/s10522-021-09936-9
Abstract: An intricate relationship between impaired immune functions and the age-related accumulation of tissue senescent cells is rapidly emerging. The immune system is unique as it undergoes mutually inclusive and deleterious processes of immunosenescence and cellular… read more here.
Keywords: senescence; immunosenescence; biology; macrophage ... See more keywords
Caveolin-1, a master regulator of cellular senescence
Sign Up to like & getrecommendations! Published in 2020 at "Cancer and Metastasis Reviews"
DOI: 10.1007/s10555-020-09875-w
Abstract: Cellular senescence is a feature of most somatic cells. It is characterized by an irreversible cell cycle arrest and by the ability to secrete a plethora of mediators of inflammation and growth factors, which can… read more here.
Keywords: senescent cells; senescence; cellular senescence; cancer ... See more keywords
Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation
Sign Up to like & getrecommendations! Published in 2018 at "GeroScience"
DOI: 10.1007/s11357-018-0047-6
Abstract: Aging-induced pro-inflammatory phenotypic alterations of the cerebral vasculature critically contribute to the pathogenesis of vascular cognitive impairment. Cellular senescence is a fundamental aging process that promotes inflammation; however, its role in cerebrovascular aging remains unexplored.… read more here.
Keywords: age related; senescence; inflammation; nrf2 deficiency ... See more keywords