Mimicking Cellular Signaling Pathways within Synthetic Multicompartment Vesicles with Triggered Enzyme Activity and Induced Ion Channel Recruitment
Sign Up to like & getrecommendations! Published in 2019 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201904267
Abstract: Subcellular compartmentalization of cells, a defining characteristic of eukaryotes, is fundamental for the fine tuning of internal processes and the responding to external stimuli. Reproducing and controlling such compartmentalized hierarchical organization, responsiveness, and communication is… read more here.
Keywords: signaling pathways; cellular signaling; activity; multicompartment ... See more keywords
Visual analytics of cellular signaling data
Sign Up to like & getrecommendations! Published in 2018 at "Multimedia Tools and Applications"
DOI: 10.1007/s11042-018-6966-5
Abstract: Cellular signaling data is a type of traffic data, which contains rich spatio-temporal information. Rather than studying the trajectories of individuals, we propose a visual analytics methodology to analyze the crowd flows among a geographical… read more here.
Keywords: visual analytics; methodology; analytics cellular; cellular signaling ... See more keywords
Cellular Signaling Analysis shows antiviral, ribavirin-mediated ribosomal signaling modulation
Sign Up to like & getrecommendations! Published in 2019 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2019.104598
Abstract: Abstract As antiviral drug resistance develops and new viruses emerge there is a pressing need to develop strategies to rapidly develop antiviral therapeutics. Here we use phospho-specific flow cytometry to assess perturbations of many different… read more here.
Keywords: ribavirin; antiviral drug; cellular signaling; drug ... See more keywords
Cellular signaling in pseudoxanthoma elasticum: an update.
Sign Up to like & getrecommendations! Published in 2019 at "Cellular signalling"
DOI: 10.1016/j.cellsig.2018.12.009
Abstract: Pseudoxanthoma elasticum is an autosomal recessive genodermatosis with variable expression, due to mutations in the ABCC6 or ENPP1 gene. It is characterized by elastic fiber mineralization and fragmentation, resulting in skin, eye and cardiovascular symptoms.… read more here.
Keywords: elasticum update; signaling pseudoxanthoma; cellular signaling; pseudoxanthoma elasticum ... See more keywords
Hispolon: A natural polyphenol and emerging cancer killer by multiple cellular signaling pathways
Sign Up to like & getrecommendations! Published in 2020 at "Environmental Research"
DOI: 10.1016/j.envres.2020.110017
Abstract: Abstract Nature as an infinite treasure of chemotypes and pharmacophores will continue to play an imperative role in the drug discovery. Natural products (NPs) such as plant and fungal metabolites have emerged as leads in… read more here.
Keywords: hispolon; signaling pathways; cellular signaling; drug ... See more keywords
Oncogenic Activities of IDH1/2 Mutations: From Epigenetics to Cellular Signaling.
Sign Up to like & getrecommendations! Published in 2017 at "Trends in cell biology"
DOI: 10.1016/j.tcb.2017.06.002
Abstract: Gliomas and leukemias remain highly refractory to treatment, thus highlighting the need for new and improved therapeutic strategies. Mutations in genes encoding enzymes involved in the tricarboxylic acid (TCA) cycle, such as the isocitrate dehydrogenases… read more here.
Keywords: activities idh1; oncogenic activities; idh1 mutations; mutations epigenetics ... See more keywords
The Capture of Cadmium by Reactive Polysulfides Attenuates Cadmium-Induced Adaptive Responses and Hepatotoxicity.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical research in toxicology"
DOI: 10.1021/acs.chemrestox.7b00278
Abstract: Cadmium (Cd) is an environmental electrophile that modifies protein nucleophiles, thereby modulating cellular signaling and toxicity. While reactive persulfides/polysulfides exhibit relatively high nucleophilic properties, their roles in the altered gene expression and toxicity caused by… read more here.
Keywords: reactive polysulfides; cellular signaling; cadmium; hepatotoxicity ... See more keywords
The Signaling Pathways Project, an integrated ‘omics knowledgebase for mammalian cellular signaling pathways
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Data"
DOI: 10.1038/s41597-019-0193-4
Abstract: Mining of integrated public transcriptomic and ChIP-Seq (cistromic) datasets can illuminate functions of mammalian cellular signaling pathways not yet explored in the research literature. Here, we designed a web knowledgebase, the Signaling Pathways Project (SPP),… read more here.
Keywords: signaling pathways; transcriptomic cistromic; cellular signaling; mammalian cellular ... See more keywords
Non-proteolytic ubiquitylation in cellular signaling and human disease
Sign Up to like & getrecommendations! Published in 2022 at "Communications Biology"
DOI: 10.1038/s42003-022-03060-1
Abstract: Ubiquitylation is one of the most common post-translational modifications (PTMs) of proteins that frequently targets substrates for proteasomal degradation. However it can also result in non-proteolytic events which play important functions in cellular processes such… read more here.
Keywords: cellular signaling; ubiquitylation; non proteolytic; disease ... See more keywords
Cellular Signaling in Müller Glia: Progenitor Cells for Regenerative and Neuroprotective Responses in Pharmacological Models of Retinal Degeneration
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Ophthalmology"
DOI: 10.1155/2019/5743109
Abstract: Retinal degenerative diseases are a leading cause of visual impairment or blindness. There are many therapies for delaying the progression of vision loss but no curative strategies currently. Stimulating intrinsic neuronal regeneration is a potential… read more here.
Keywords: ller glia; cellular signaling; glia; signaling ller ... See more keywords
The Importance of Tyrosine Phosphorylation Control of Cellular Signaling Pathways in Respiratory Disease: pY and pY Not
Sign Up to like & getrecommendations! Published in 2018 at "American Journal of Respiratory Cell and Molecular Biology"
DOI: 10.1165/rcmb.2018-0049tr
Abstract: &NA; Reversible phosphorylation of proteins on tyrosine residues is an essential signaling mechanism by which diverse cellular processes are closely regulated. The tight temporal and spatial control of the tyrosine phosphorylation status of proteins by… read more here.
Keywords: tyrosine phosphorylation; control; cellular signaling; disease ... See more keywords