Decomposing Oncogenic Transcriptional Signatures to Generate Maps of Divergent Cellular States.
Sign Up to like & getrecommendations! Published in 2017 at "Cell systems"
DOI: 10.1016/j.cels.2017.08.002
Abstract: The systematic sequencing of the cancer genome has led to the identification of numerous genetic alterations in cancer. However, a deeper understanding of the functional consequences of these alterations is necessary to guide appropriate therapeutic strategies. Here,… read more here.
Keywords: cellular states; transcriptional signatures; generate maps; decomposing oncogenic ... See more keywords
Tumor microenvironment is critical for the maintenance of cellular states found in primary glioblastomas.
Sign Up to like & getrecommendations! Published in 2020 at "Cancer discovery"
DOI: 10.1158/2159-8290.cd-20-0057
Abstract: Glioblastoma, an incurable tumor, remains difficult to model and more importantly to treat due to its genetic/epigenetic heterogeneity and plasticity across cellular states. The ability of current tumor models to recapitulate the cellular states found… read more here.
Keywords: cellular states; tumor; found primary; states found ... See more keywords
Probing transient memory of cellular states using single-cell lineages
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2022.1050516
Abstract: The inherent stochasticity in the gene product levels can drive single cells within an isoclonal population to different phenotypic states. The dynamic nature of this intercellular variation, where individual cells can transition between different states… read more here.
Keywords: cell; transient memory; single cell; cellular states ... See more keywords