Severe Uncontrolled Maternal Hyperglycemia Induces Microsomia and Neurodevelopment Delay Accompanied by Apoptosis, Cellular Survival, and Neuroinflammatory Deregulation in Rat Offspring Hippocampus
Sign Up to like & getrecommendations! Published in 2019 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-019-00658-8
Abstract: Maternal diabetes constitutes an unfavorable intrauterine environment for offspring development. Although it is known that diabetes can cause brain alterations and increased risk for neurologic disorders, the relationship between neuroimmune activation, brain changes, and neurodevelopment… read more here.
Keywords: uncontrolled maternal; cellular survival; hippocampus; severe uncontrolled ... See more keywords
Evidence that melatonin downregulates Nedd4-1 E3 ligase and its role in cellular survival.
Sign Up to like & getrecommendations! Published in 2019 at "Toxicology and applied pharmacology"
DOI: 10.1016/j.taap.2019.114686
Abstract: Indolamine melatonin structurally resembles non-covalent proteasome inhibitors; however, the role of ubiquitin proteasome system (UPS) in neuronal survival and how melatonin carries out UPS inhibition remain largely unknown. With the use of melatonin treated cells,… read more here.
Keywords: cellular survival; downregulates nedd4; role; melatonin ... See more keywords
IRF2 regulates cellular survival and Lenvatinib-sensitivity of hepatocellular carcinoma (HCC) through regulating β-catenin
Sign Up to like & getrecommendations! Published in 2021 at "Translational Oncology"
DOI: 10.1016/j.tranon.2021.101059
Abstract: Highlights • IRF2 and β-catenin are highly expressed in HCC tissues.• IRF2 upregulation of β-catenin promotes HCC cell proliferation.• IRF2 enhances lenvatinib resistance in HCC cells. read more here.
Keywords: hcc; cellular survival; catenin; irf2 regulates ... See more keywords
Distributing tasks via multiple input pathways increases cellular survival in stress
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DOI: 10.7554/elife.21415
Abstract: Improving in one aspect of a task can undermine performance in another, but how such opposing demands play out in single cells and impact on fitness is mostly unknown. Here we study budding yeast in… read more here.
Keywords: input pathways; stress; cellular survival; increases cellular ... See more keywords