Tracking the cellular targets of platinum anticancer drugs: Current tools and emergent methods
Sign Up to like & getrecommendations! Published in 2019 at "Inorganica Chimica Acta"
DOI: 10.1016/j.ica.2019.118984
Abstract: Abstract Since its FDA approval just over 40 years ago, cisplatin and its more recently approved analogues, carboplatin and oxaliplatin, have been widely used to treat a spectrum of different cancers worldwide. Despite the overall success… read more here.
Keywords: platinum anticancer; tracking cellular; targets platinum; cellular targets ... See more keywords
Synthesis and cellular evaluation of click-chemistry probes to study the biological effects of alpha, beta-unsaturated carbonyls
Sign Up to like & getrecommendations! Published in 2022 at "Redox Biology"
DOI: 10.1016/j.redox.2022.102299
Abstract: Humans are commonly exposed to α,β-unsaturated carbonyls as both environmental toxins (e.g. acrolein) and therapeutic drugs (e.g. dimethylfumarate, DMFU, a front-line drug for the treatment of multiple sclerosis and psoriasis). These compounds undergo rapid Michael… read more here.
Keywords: chemistry; cellular targets; unsaturated carbonyls; synthesis cellular ... See more keywords
Cellular targets of mefloquine.
Sign Up to like & getrecommendations! Published in 2021 at "Toxicology"
DOI: 10.1016/j.tox.2021.152995
Abstract: Mefloquine is a quinoline-based compound widely used as an antimalarial drug, particularly in chemoprophylaxis. Although decades of research have identified various aspects of mefloquine's anti-Plasmodium properties, toxic effects offset its robust use in humans. Mefloquine… read more here.
Keywords: cellular targets; targets mefloquine; toxicology;
Competitive affinity-based proteome profiling and imaging to reveal potential cellular targets of betulinic acid.
Sign Up to like & getrecommendations! Published in 2017 at "Chemical communications"
DOI: 10.1039/c7cc04190j
Abstract: Betulinic acid (BA), a pentacyclic triterpenoid natural product, has received considerable attention owing to the broad spectrum of biological activities such as anti-HIV, anti-inflammatory, and especially, antitumor. Despite numerous studies on the antitumor mechanisms over… read more here.
Keywords: potential cellular; competitive affinity; proteome profiling; betulinic acid ... See more keywords
The microbiome-product colibactin hits unique cellular targets mediating host–microbe interaction
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.958012
Abstract: The human microbiota produces molecules that are evolved to interact with the diverse cellular machinery of both the host and microbes, mediating health and diseases. One of the most puzzling microbiome molecules is colibactin, a… read more here.
Keywords: colibactin hits; colibactin; mediating host; cellular targets ... See more keywords