Converging cellular themes for the hereditary spastic paraplegias
Sign Up to like & getrecommendations! Published in 2018 at "Current Opinion in Neurobiology"
DOI: 10.1016/j.conb.2018.04.025
Abstract: Hereditary spastic paraplegias (HSPs) are neurologic disorders characterized by prominent lower-extremity spasticity, resulting from a length-dependent axonopathy of corticospinal upper motor neurons. They are among the most genetically-diverse neurologic disorders, with >80 distinct genetic loci… read more here.
Keywords: hereditary spastic; cellular themes; spastic paraplegias; converging cellular ... See more keywords
Emerging cellular themes in leukodystrophies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.902261
Abstract: Leukodystrophies are a broad spectrum of neurological disorders that are characterized primarily by deficiencies in myelin formation. Clinical manifestations of leukodystrophies usually appear during childhood and common symptoms include lack of motor coordination, difficulty with… read more here.
Keywords: cellular themes; themes leukodystrophies; biology; emerging cellular ... See more keywords