Polη, a Y-family translesion synthesis polymerase, promotes cellular tolerance of Myc-induced replication stress
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DOI: 10.1242/jcs.212183
Abstract: ABSTRACT Growth of precancerous and cancer cells relies on their tolerance of oncogene-induced replication stress (RS). Translesion synthesis (TLS) plays an essential role in the cellular tolerance of various types of RS and bypasses replication… read more here.
Keywords: myc induced; polymerase; cellular tolerance; replication ... See more keywords
Cellular tolerance at the µ-opioid receptor is phosphorylation dependent
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DOI: 10.7554/elife.34989
Abstract: Phosphorylation of the μ-opioid receptor (MOR) is known as a key step in desensitization and internalization but the role in the development of long-term tolerance at the cellular level is not known. Viral expression of… read more here.
Keywords: opioid receptor; tolerance; tolerance opioid; cellular tolerance ... See more keywords