Combination of Surface Charge and Size Controls the Cellular Uptake of Functionalized Graphene Sheets
Sign Up to like & getrecommendations! Published in 2017 at "Advanced Functional Materials"
DOI: 10.1002/adfm.201701837
Abstract: A fundamental issue for biomedical applications of graphene is the correlation between its physicochemical properties and cellular uptake mechanism. However, such studies are challenging due to the intrinsic polydispersity of graphene. In this work, a… read more here.
Keywords: surface charge; size; cellular uptake; graphene sheets ... See more keywords
Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake
Sign Up to like & getrecommendations! Published in 2017 at "Peptide Science"
DOI: 10.1002/bip.23025
Abstract: Chlorotoxin (CTX), a disulfide‐rich peptide from the scorpion Leiurus quinquestriatus, has several promising biopharmaceutical properties, including preferential affinity for certain cancer cells, high serum stability, and cell penetration. These properties underpin its potential for use… read more here.
Keywords: ctx; arginine mutagenesis; lysine arginine; mutagenesis chlorotoxin ... See more keywords
Controlling Cellular Uptake and Toxicity of Polyphenylene Dendrimers by Chemical Functionalization
Sign Up to like & getrecommendations! Published in 2017 at "ChemBioChem"
DOI: 10.1002/cbic.201700079
Abstract: Polyphenylene dendrimers (PPDs) represent a unique class of macromolecules based on their monodisperse and shape‐persistent nature. These characteristics have enabled the synthesis of a new genre of “patched” surface dendrimers, where their exterior can be… read more here.
Keywords: uptake toxicity; controlling cellular; cellular uptake; polyphenylene dendrimers ... See more keywords
Thiol‐Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers
Sign Up to like & getrecommendations! Published in 2020 at "ChemBioChem"
DOI: 10.1002/cbic.202000303
Abstract: The intracellular transport of molecules, macromolecules or materials is a key step in probing cellular structure and function, as well as regulating a plethora of physical and chemical events for treating disease. This communication reveals… read more here.
Keywords: highly efficient; uptake; pyridyl disulfide; uptake pyridyl ... See more keywords
Cationic and Neutral N‐Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI‐60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation
Sign Up to like & getrecommendations! Published in 2018 at "ChemMedChem"
DOI: 10.1002/cmdc.201800181
Abstract: A structurally diverse library of 14 gold(I) cationic bis(NHC) and neutral mono(NHC) complexes (NHC: N‐heterocyclic carbene) was synthesized and characterized in this work. Four of them were new cationic gold(I) complexes containing functionalized NHCs, and… read more here.
Keywords: thioredoxin reductase; gold; cytotoxicity; gold complexes ... See more keywords
Influence of the mechanical and geometrical parameters on the cellular uptake of nanoparticles: a stochastic approach.
Sign Up to like & getrecommendations! Published in 2022 at "International journal for numerical methods in biomedical engineering"
DOI: 10.1002/cnm.3598
Abstract: Nanoparticles (NPs) are used for drug delivery with enhanced selectivity and reduced side-effect toxicity in cancer treatments. Based on the literature, the influence of the NPs mechanical and geometrical properties on their cellular uptake has… read more here.
Keywords: parameters cellular; influence mechanical; geometrical parameters; mechanical geometrical ... See more keywords
Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake.
Sign Up to like & getrecommendations! Published in 2021 at "Macromolecular bioscience"
DOI: 10.1002/mabi.202100005
Abstract: Nanomedicine has gained much attention for the management and treatment of cancers due to the distinctive physicochemical properties of the drug-loaded particles. Chitosan's cationic nature is attractive for the development of such particles for drug… read more here.
Keywords: chitosan particles; delivery; delivery cellular; cellular uptake ... See more keywords
The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo.
Sign Up to like & getrecommendations! Published in 2017 at "Small"
DOI: 10.1002/smll.201701815
Abstract: Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of… read more here.
Keywords: nms cellular; uptake vitro; cellular uptake; vitro vivo ... See more keywords
Probing the Effect of Rigidity on the Cellular Uptake of Core-Shell Nanoparticles: Stiffness Effects are Size Dependent.
Sign Up to like & getrecommendations! Published in 2022 at "Small"
DOI: 10.1002/smll.202203070
Abstract: Nanoparticles are well established vectors for the delivery of a wide range of biomedically relevant cargoes. Numerous studies have investigated the impact of size, shape, charge, and surface functionality of nanoparticles on mammalian cellular uptake.… read more here.
Keywords: rigidity; cellular uptake; core shell; size dependent ... See more keywords
In vitro cellular uptake and neuroprotective efficacy of poly-arginine-18 (R18) and poly-ornithine-18 (O18) peptides: critical role of arginine guanidinium head groups for neuroprotection
Sign Up to like & getrecommendations! Published in 2019 at "Molecular and Cellular Biochemistry"
DOI: 10.1007/s11010-019-03646-0
Abstract: We have previously demonstrated that Cationic Arginine-Rich Peptides (CARPs) and in particular poly-arginine-18 (R18; 18-mer of arginine) exhibit potent neuroprotective properties in both in vitro and in vivo neuronal injury models. Based on the current… read more here.
Keywords: head; r18; head groups; arginine ... See more keywords
The Effect of Surface Charges on the Cellular Uptake of Liposomes Investigated by Live Cell Imaging
Sign Up to like & getrecommendations! Published in 2017 at "Pharmaceutical Research"
DOI: 10.1007/s11095-017-2097-3
Abstract: PurposeLiposomes have been developed as versatile nanocarriers for various pharmacological agents. The effect of surface charges on the cellular uptake of the liposomes has been studied by various methods using mainly fixed cells with inevitable… read more here.
Keywords: live cell; charges cellular; surface charges; cell ... See more keywords