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   Articles with "cellular uptake" as a keyword



Combination of Surface Charge and Size Controls the Cellular Uptake of Functionalized Graphene Sheets

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recommendations! Published in 2017 at "Advanced Functional Materials"

DOI: 10.1002/adfm.201701837

Abstract: A fundamental issue for biomedical applications of graphene is the correlation between its physicochemical properties and cellular uptake mechanism. However, such studies are challenging due to the intrinsic polydispersity of graphene. In this work, a… read more here.

Keywords: surface charge; size; cellular uptake; graphene sheets ... See more keywords

Cellular Uptake of Phase‐Separating Peptide Coacervates

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recommendations! Published in 2024 at "Advanced Science"

DOI: 10.1002/advs.202402652

Abstract: Peptide coacervates self‐assembling via liquid‐liquid phase separation are appealing intracellular delivery vehicles of macromolecular therapeutics (proteins, DNA, mRNA) owing to their non‐cytotoxicity, high encapsulation capacity, and efficient cellular uptake. However, the mechanisms by which these… read more here.

Keywords: peptide coacervates; cellular uptake; phase separating; uptake phase ... See more keywords

Lysine to arginine mutagenesis of chlorotoxin enhances its cellular uptake

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recommendations! Published in 2017 at "Peptide Science"

DOI: 10.1002/bip.23025

Abstract: Chlorotoxin (CTX), a disulfide‐rich peptide from the scorpion Leiurus quinquestriatus, has several promising biopharmaceutical properties, including preferential affinity for certain cancer cells, high serum stability, and cell penetration. These properties underpin its potential for use… read more here.

Keywords: ctx; arginine mutagenesis; lysine arginine; mutagenesis chlorotoxin ... See more keywords
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Controlling Cellular Uptake and Toxicity of Polyphenylene Dendrimers by Chemical Functionalization

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recommendations! Published in 2017 at "ChemBioChem"

DOI: 10.1002/cbic.201700079

Abstract: Polyphenylene dendrimers (PPDs) represent a unique class of macromolecules based on their monodisperse and shape‐persistent nature. These characteristics have enabled the synthesis of a new genre of “patched” surface dendrimers, where their exterior can be… read more here.

Keywords: uptake toxicity; controlling cellular; cellular uptake; polyphenylene dendrimers ... See more keywords
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Thiol‐Disulfide Exchange Reaction Promoted Highly Efficient Cellular Uptake of Pyridyl Disulfide Appended Nonionic Polymers

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recommendations! Published in 2020 at "ChemBioChem"

DOI: 10.1002/cbic.202000303

Abstract: The intracellular transport of molecules, macromolecules or materials is a key step in probing cellular structure and function, as well as regulating a plethora of physical and chemical events for treating disease. This communication reveals… read more here.

Keywords: highly efficient; uptake; pyridyl disulfide; uptake pyridyl ... See more keywords

PCFT‐Independent Cellular Uptake of Cyclic Cell‐Penetrating Peptide‐Conjugated Folic Acid

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recommendations! Published in 2025 at "Chembiochem"

DOI: 10.1002/cbic.202500242

Abstract: Folic acid is an essential component of many metabolic processes, including the synthesis of nucleoproteins, purines, and pyrimidines, and is a recommended supplement to lower the incidence of various disorders. Folic acid and folate‐loaded nanoparticles… read more here.

Keywords: folic acid; penetrating peptide; cellular uptake; acid ... See more keywords

Cationic and Neutral N‐Heterocyclic Carbene Gold(I) Complexes: Cytotoxicity, NCI‐60 Screening, Cellular Uptake, Inhibition of Mammalian Thioredoxin Reductase, and Reactive Oxygen Species Formation

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recommendations! Published in 2018 at "ChemMedChem"

DOI: 10.1002/cmdc.201800181

Abstract: A structurally diverse library of 14 gold(I) cationic bis(NHC) and neutral mono(NHC) complexes (NHC: N‐heterocyclic carbene) was synthesized and characterized in this work. Four of them were new cationic gold(I) complexes containing functionalized NHCs, and… read more here.

Keywords: thioredoxin reductase; gold; cytotoxicity; gold complexes ... See more keywords
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Influence of the mechanical and geometrical parameters on the cellular uptake of nanoparticles: a stochastic approach.

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recommendations! Published in 2022 at "International journal for numerical methods in biomedical engineering"

DOI: 10.1002/cnm.3598

Abstract: Nanoparticles (NPs) are used for drug delivery with enhanced selectivity and reduced side-effect toxicity in cancer treatments. Based on the literature, the influence of the NPs mechanical and geometrical properties on their cellular uptake has… read more here.

Keywords: parameters cellular; influence mechanical; geometrical parameters; mechanical geometrical ... See more keywords
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Chitosan Nanomedicine in Cancer Therapy: Targeted Delivery and Cellular Uptake.

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recommendations! Published in 2021 at "Macromolecular bioscience"

DOI: 10.1002/mabi.202100005

Abstract: Nanomedicine has gained much attention for the management and treatment of cancers due to the distinctive physicochemical properties of the drug-loaded particles. Chitosan's cationic nature is attractive for the development of such particles for drug… read more here.

Keywords: chitosan particles; delivery; delivery cellular; cellular uptake ... See more keywords

Poly(2-Oxazoline)-Based Polyphotoacids: Synthesis, Solution Behavior, and Cellular Uptake of Multi-Responsive Intracellular Transporters.

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recommendations! Published in 2025 at "Macromolecular rapid communications"

DOI: 10.1002/marc.202500455

Abstract: This work describes the first polymeric photoacids based on poly(2-oxazoline)s. The presence of 1-hydroxypyrene units-a photoacid that can increase its acidity upon blue light irradiation through excited-state proton transfer-allows remote control over material polarity and… read more here.

Keywords: poly oxazoline; polyphotoacids synthesis; oxazoline based; based polyphotoacids ... See more keywords

The Effects of Physicochemical Properties of Nanomaterials on Their Cellular Uptake In Vitro and In Vivo.

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recommendations! Published in 2017 at "Small"

DOI: 10.1002/smll.201701815

Abstract: Understanding the cellular uptake of nanomaterials (NMs) is a fundamental and critical issue for uncovering biomedical effects of NMs and facilitating their practical applications in the clinic. In this Review, by highlighting the differences of… read more here.

Keywords: nms cellular; uptake vitro; cellular uptake; vitro vivo ... See more keywords