Molecular glue CELMoD compounds are regulators of cereblon conformation
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DOI: 10.1126/science.add7574
Abstract: Cereblon (CRBN) is a ubiquitin ligase (E3) substrate receptor protein co-opted by CRBN E3 ligase modulatory drug (CELMoD) agents that target therapeutically relevant proteins for degradation. Prior crystallographic studies defined the drug-binding site within CRBN’s… read more here.
Keywords: cereblon; celmod compounds; conformation; drug ... See more keywords