CEMIP, a novel adaptor protein of OGT, promotes colorectal cancer metastasis through glutamine metabolic reprogramming via reciprocal regulation of β-catenin
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-021-02023-w
Abstract: Metastasis is the leading cause of colorectal cancer (CRC)-induced death. However, the underlying molecular mechanisms of CRC metastasis are poorly understood. Metabolic reprogramming is an intrinsic feature of cancer, which have complicated effects on cancer… read more here.
Keywords: protein; metabolic reprogramming; cemip; metastasis ... See more keywords
CEMIP as a prognostic biomarker for cancers: a meta- and bioinformatic analysis
Sign Up to like & getrecommendations! Published in 2022 at "Expert Review of Molecular Diagnostics"
DOI: 10.1080/14737159.2022.2168191
Abstract: ABSTRACT Objective Cell migration-inducing and hyaluronan-binding protein (CEMIP) is overexpressed in several cancers and is related to prognosis in cancer patients. Here, we conducted a meta-analysis to explore the prognostic effects of CEMIP in cancer… read more here.
Keywords: prognostic biomarker; analysis; cancer patients; cemip ... See more keywords
CEMIP promotes extracellular matrix-detached prostate cancer cells survival by inhibiting ferroptosis.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer science"
DOI: 10.1111/cas.15356
Abstract: Cells detached from the extracellular matrix (ECM) can trigger different modes of cell death, and the survival of ECM-detached cells is one of the prerequisites for the metastatic cascade. Ferroptosis, a form of iron-dependent programmed… read more here.
Keywords: ferroptosis; cancer cells; extracellular matrix; matrix detached ... See more keywords
Tumor CEMIP drives immune evasion of colorectal cancer via MHC-I internalization and degradation
Sign Up to like & getrecommendations! Published in 2023 at "Journal for Immunotherapy of Cancer"
DOI: 10.1136/jitc-2022-005592
Abstract: Background Loss of major histocompatibility complex class I (MHC-I) in tumor cells limits the use of immune checkpoint blockade (ICB) in colorectal cancer. Nevertheless, the regulatory mechanism of MHC-I downregulation in tumor cells has not… read more here.
Keywords: mhc; internalization; colorectal cancer; tumor ... See more keywords
CEMIP Promotes Osteosarcoma Progression and Metastasis Through Activating Notch Signaling Pathway
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2022.919108
Abstract: Cell migration inducing protein (CEMIP) has been linked to carcinogenesis in several types of cancers. However, the role and mechanism of CEMIP in osteosarcoma remain unclear. This study investigated the role of CEMIP in the… read more here.
Keywords: metastasis; notch signaling; osteosarcoma; signaling pathway ... See more keywords
CEMIP, a Promising Biomarker That Promotes the Progression and Metastasis of Colorectal and Other Types of Cancer
Sign Up to like & getrecommendations! Published in 2022 at "Cancers"
DOI: 10.3390/cancers14205093
Abstract: Simple Summary CEMIP (cell migration-inducing and hyaluronan-binding protein) has been implicated in the pathogenesis of numerous diseases, including colorectal and other forms of cancer. The molecular functions of CEMIP are currently under investigation and include… read more here.
Keywords: metastasis; colorectal types; promising biomarker; cancer ... See more keywords
CEMIP as a potential biomarker and therapeutic target for breast cancer patients
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Medical Sciences"
DOI: 10.7150/ijms.58067
Abstract: Purpose: We aimed to evaluate whether CEMIP plays any role in the survival outcome of breast cancer (BC) patients, as well as to explore the regulatory mechanism of CEMIP in BC. Methods: We evaluated the… read more here.
Keywords: cancer patients; potential biomarker; expression; breast cancer ... See more keywords
Central Role of CEMIP in Tumorigenesis and Its Potential as Therapeutic Target
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DOI: 10.7150/jca.19295
Abstract: CEMIP (KIAA1199) was identified as migratory indicator protein which had been crudely studied in the last decade. Firstly its mutation site was reported to cause hearing loss due to the folding change of protein structure,… read more here.
Keywords: cemip; target; cemip tumorigenesis; role ... See more keywords