In vitro characterization of baloxavir acid, a first‐in‐class cap‐dependent endonuclease inhibitor of the influenza virus polymerase PA subunit
Sign Up to like & getrecommendations! Published in 2018 at "Antiviral Research"
DOI: 10.1016/j.antiviral.2018.10.008
Abstract: ABSTRACT Cap‐dependent endonuclease (CEN) resides in the PA subunit of the influenza virus and mediates the critical “cap‐snatching” step of viral RNA transcription, which is considered to be a promising anti‐influenza target. Here, we describe… read more here.
Keywords: bxa; inhibitor; baloxavir acid; vitro characterization ... See more keywords
Cerium nitrate stiffens in-vitro skin models and reduces Pseudomonas aeruginosa pathogenicity and penetration through skin models.
Sign Up to like & getrecommendations! Published in 2022 at "Advances in wound care"
DOI: 10.1089/wound.2022.0026
Abstract: OBJECTIVE Cerium nitrate (CeN) plus silver sulfadiazine (SSD) cream has been used for 40-plus years to manage burns. CeN produces a hardened eschar believed to resist bacterial colonization/infection. To evaluate this potential mechanism, we treated… read more here.
Keywords: skin models; skin; vitro skin; penetration ... See more keywords
TESS photometry of extreme helium stars PV Tel and V821 Cen
Sign Up to like & getrecommendations! Published in 2020 at "Monthly Notices of the Royal Astronomical Society"
DOI: 10.1093/mnrasl/slaa075
Abstract: PV Tel variables are extreme helium (EHe) stars known to be intrinsic light and velocity variable on characteristic timescales 0.1 - 2 d. With two exceptions, they are best described as irregular. Light curves have… read more here.
Keywords: tess photometry; cen; v821 cen; extreme helium ... See more keywords
Cis- and Trans-chromosomal Interactions Define Pericentric Boundaries in the Absence of Conventional Heterochromatin
Sign Up to like & getrecommendations! Published in 2019 at "Genetics"
DOI: 10.1534/genetics.119.302179
Abstract: The molecular cues for CENPA positioning in epigenetically regulated centromeres is elusive. Candida albicans has small regional non-repetitive centromeres that do not harbor conventional heterochromatin. Deletion of native centromere leads to activation of a neocentromere...… read more here.
Keywords: chromosomal interactions; conventional heterochromatin; cen; trans chromosomal ... See more keywords
Centromere and Pericentromere Transcription: Roles and Regulation … in Sickness and in Health
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Genetics"
DOI: 10.3389/fgene.2018.00674
Abstract: The chromosomal loci known as centromeres (CEN) mediate the equal distribution of the duplicated genome between both daughter cells. Specifically, centromeres recruit a protein complex named the kinetochore, that bi-orients the replicated chromosome pairs to… read more here.
Keywords: transcription; centromere pericentromere; kinetochore; transcription roles ... See more keywords
Carotenoid-Enriched Nanoemulsions and γ-Rays Synergistically Induce Cell Death in a Novel Radioresistant Osteosarcoma Cell Line
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms232415959
Abstract: We previously demonstrated that SAOS human osteosarcoma cells, incubated with carotenoid-enriched nanoemulsions (CEN), activated a nonprotective form of autophagy and delayed cell proliferation. The present work focuses on the biological effects of CEN on a… read more here.
Keywords: cell death; cell; carotenoid enriched; enriched nanoemulsions ... See more keywords