Burkholderia cenocepacia utilizes a type VI secretion system for bacterial competition
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DOI: 10.1002/mbo3.774
Abstract: Burkholderia cenocepacia is an opportunistic bacterial pathogen that poses a significant threat to individuals with cystic fibrosis by provoking a strong inflammatory response within the lung. It possesses a type VI secretion system (T6SS), a… read more here.
Keywords: cenocepacia; system; burkholderia cenocepacia; t6ss ... See more keywords
The Burkholderia cenocepacia iron starvation σ factor, OrbS, possesses an on-board iron sensor
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac137
Abstract: Abstract Burkholderia cenocepacia is an opportunistic pathogen that causes severe infections of the cystic fibrosis (CF) lung. To acquire iron, B. cenocepacia secretes the Fe(III)-binding compound, ornibactin. Genes for synthesis and utilisation of ornibactin are… read more here.
Keywords: burkholderia cenocepacia; iron; cenocepacia; factor orbs ... See more keywords
Staphylococcus aureus products subvert the Burkholderia cenocepacia-induced inflammatory response in airway epithelial cells.
Sign Up to like & getrecommendations! Published in 2019 at "Journal of medical microbiology"
DOI: 10.1099/jmm.0.001100
Abstract: Aim. This study aims to investigate the differences in host responses to mono- and co-infection with S. aureus and B. cenocepacia in human airway epithelial cells.Methodology. We assessed the effect of co-infection with B. cenocepacia… read more here.
Keywords: cenocepacia; epithelial cells; aureus; inflammatory response ... See more keywords
Comparative analysis of the Burkholderia cenocepacia K56-2 essential genome reveals cell envelope functions that are uniquely required for survival in species of the genus Burkholderia
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DOI: 10.1099/mgen.0.000140
Abstract: Burkholderia cenocepacia K56-2 belongs to the Burkholderia cepacia complex, a group of Gram-negative opportunistic pathogens that have large and dynamic genomes. In this work, we identified the essential genome of B. cenocepacia K56-2 using high-density… read more here.
Keywords: essential genome; cenocepacia; cenocepacia k56; burkholderia cenocepacia ... See more keywords
Targeting the Nonmevalonate Pathway in Burkholderia cenocepacia Increases Susceptibility to Certain β-Lactam Antibiotics
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DOI: 10.1128/aac.02607-17
Abstract: ABSTRACT The nonmevalonate pathway is the sole pathway for isoprenoid biosynthesis in Burkholderia cenocepacia and is possibly a novel target for the development of antibacterial chemotherapy. The goals of the present study were to evaluate… read more here.
Keywords: cenocepacia; susceptibility; lactam antibiotics; burkholderia cenocepacia ... See more keywords
Pellicle Biofilm Formation in Burkholderia cenocepacia J2315 is Epigenetically Regulated through WspH, a Hybrid Two-Component System Kinase-Response Regulator
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Bacteriology"
DOI: 10.1128/jb.00017-22
Abstract: Biofilms are surface-attached or suspended aggregates of cells, that are problematic in the context of bacterial infections, as they provide protection from antibiotic treatment. Burkholderia cenocepacia can colonize the lung of immunocompromised patients and forms… read more here.
Keywords: biofilm formation; burkholderia cenocepacia; wsph; pellicle biofilm ... See more keywords
Genetic Determinants Associated With in Vivo Survival of Burkholderia cenocepacia in the Caenorhabditis elegans Model
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Microbiology"
DOI: 10.3389/fmicb.2018.01118
Abstract: A Burkholderia cenocepacia infection usually leads to reduced survival and fatal cepacia syndrome in cystic fibrosis patients. The identification of B. cenocepacia essential genes for in vivo survival is key to designing new anti-infectives therapies.… read more here.
Keywords: cenocepacia; burkholderia cenocepacia; caenorhabditis elegans; vivo survival ... See more keywords
Environmental Burkholderia cenocepacia Strain Enhances Fitness by Serial Passages during Long-Term Chronic Airways Infection in Mice
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DOI: 10.3390/ijms18112417
Abstract: Burkholderia cenocepacia is an important opportunistic pathogen in cystic fibrosis (CF) patients, and has also been isolated from natural environments. In previous work, we explored the virulence and pathogenic potential of environmental B. cenocepacia strains… read more here.
Keywords: cenocepacia; serial passages; infection; mex1 ... See more keywords
Identification of Key Factors for Anoxic Survival of B. cenocepacia H111
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DOI: 10.3390/ijms23094560
Abstract: Burkholderia cenocepacia is an opportunistic pathogen that can lead to severe infections in patients suffering from cystic fibrosis (CF) and chronic granulomatous disease. Being an obligate aerobe, B. cenocepacia is unable to grow in the… read more here.
Keywords: identification key; cenocepacia; cenocepacia h111; key factors ... See more keywords
Characterization of the Burkholderia cenocepacia TonB Mutant as a Potential Live Attenuated Vaccine
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DOI: 10.3390/vaccines5040033
Abstract: Burkholderia cenocepacia is an opportunistic pathogen prevalent in cystic fibrosis patients, which is particularly difficult to treat, causing chronic and eventually fatal infections. The lack of effective treatment options makes evident the need to develop… read more here.
Keywords: cenocepacia; burkholderia cenocepacia; live attenuated; cenocepacia tonb ... See more keywords