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   Articles with "cenp" as a keyword



Concurrent Duplication of Drosophila Cid and Cenp-C Genes Resulted in Accelerated Evolution and Male Germline-Biased Expression of the New Copies

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recommendations! Published in 2018 at "Journal of Molecular Evolution"

DOI: 10.1007/s00239-018-9851-y

Abstract: Despite their essential role in the process of chromosome segregation in eukaryotes, kinetochore proteins are highly diverse across species, being lost, duplicated, created, or diversified during evolution. Based on comparative genomics, the duplication of the… read more here.

Keywords: evolution; duplication; cenp; male germline ... See more keywords

Posttranslational mechanisms controlling centromere function and assembly.

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recommendations! Published in 2018 at "Current opinion in cell biology"

DOI: 10.1016/j.ceb.2018.03.003

Abstract: Accurate chromosome segregation is critical to ensure the faithful inheritance of the genome during cell division. Human chromosomes distinguish the location of the centromere from general chromatin by the selective assembly of CENP-A containing nucleosomes… read more here.

Keywords: controlling centromere; posttranslational mechanisms; cenp; centromere function ... See more keywords
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Structure of the Human Core Centromeric Nucleosome Complex

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recommendations! Published in 2019 at "Current Biology"

DOI: 10.1016/j.cub.2019.06.062

Abstract: Centromeric nucleosomes are at the interface of the chromosome and the kinetochore that connects to spindle microtubules in mitosis. The core centromeric nucleosome complex (CCNC) harbors the histone H3 variant, CENP-A, and its binding proteins, CENP-C… read more here.

Keywords: cenp; nucleosome complex; centromeric nucleosome; core centromeric ... See more keywords
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Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.

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recommendations! Published in 2020 at "Developmental cell"

DOI: 10.1016/j.devcel.2020.01.005

Abstract: Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo… read more here.

Keywords: drosophila; centromere formation; chromatin; novo centromere ... See more keywords

α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere

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recommendations! Published in 2017 at "Nature Communications"

DOI: 10.1038/ncomms14678

Abstract: Centromeres are unique chromosomal domains that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A containing nucleosomes. CENP-A governs centromere function by recruiting the constitutive centromere associated network (CCAN) complex. The… read more here.

Keywords: cenp; amino trimethylation; trimethylation cenp; nrmt required ... See more keywords

The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism

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recommendations! Published in 2019 at "Nature Communications"

DOI: 10.1038/s41467-019-08314-x

Abstract: Centromeric nucleosomes are composed of the centromere-specific histone H3 variant CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore, histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism… read more here.

Keywords: targeting domain; cenp; cenp centromere; centromere targeting ... See more keywords

The localisation and stability of the CENP-F protein are regulated by importin beta and microtubules in mitotic cells

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recommendations! Published in 2025 at "Scientific Reports"

DOI: 10.1038/s41598-025-96504-7

Abstract: CENP-F is a large protein acting in fundamental cell cycle processes, including nuclear envelope breakdown, mitotic microtubule function and chromosome segregation. These activities are mediated by specific CENP-F protein elements that interact with microtubules, motor… read more here.

Keywords: cenp; cenp protein; localisation; importin beta ... See more keywords
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A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division

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recommendations! Published in 2021 at "Communications Biology"

DOI: 10.1038/s42003-021-01861-4

Abstract: Centromere-associated protein-E (CENP-E) is a kinesin motor localizing at kinetochores. Although its mitotic functions have been well studied, it has been challenging to investigate direct consequences of CENP-E removal using conventional methods because CENP-E depletion… read more here.

Keywords: associated protein; centromere associated; cenp; cell division ... See more keywords

Insects evolved a monomeric histone-fold domain in the CENP-T protein family

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recommendations! Published in 2024 at "EMBO Reports"

DOI: 10.1038/s44319-025-00603-5

Abstract: The histone fold domain (HFD) is a conserved protein interaction module that requires stabilization through a handshake interaction with an HFD partner. All HFD proteins known to date form obligate dimers to shield the extensive… read more here.

Keywords: cenp; hfd; fold domain; histone fold ... See more keywords

Spatiotemporal regulation of CENP-E-guided chromosomes using a fast-relaxing arylazopyrazole photoswitch.

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recommendations! Published in 2024 at "Chemical communications"

DOI: 10.1039/d4cc01922a

Abstract: We developed a centromere-associated protein E (CENP-E) inhibitor employing trans to cis photoisomerization with 405 nm visible light illumination and fast thermal relaxation. This photoswitching characteristic of the inhibitor enabled selective blockage or release of… read more here.

Keywords: spatiotemporal regulation; guided chromosomes; chromosomes using; regulation cenp ... See more keywords

β-TrCP-Mediated Proteolysis of Mis18β Prevents Mislocalization of CENP-A and Chromosomal Instability

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recommendations! Published in 2024 at "Molecular and Cellular Biology"

DOI: 10.1080/10985549.2024.2382445

Abstract: Abstract Restricting the localization of evolutionarily conserved histone H3 variant CENP-A to the centromere is essential to prevent chromosomal instability (CIN), an important hallmark of cancers. Overexpressed CENP-A mislocalizes to non-centromeric regions and contributes to… read more here.

Keywords: cenp; mislocalization cenp; trcp mediated; mis18 ... See more keywords