Concurrent Duplication of Drosophila Cid and Cenp-C Genes Resulted in Accelerated Evolution and Male Germline-Biased Expression of the New Copies
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Molecular Evolution"
DOI: 10.1007/s00239-018-9851-y
Abstract: Despite their essential role in the process of chromosome segregation in eukaryotes, kinetochore proteins are highly diverse across species, being lost, duplicated, created, or diversified during evolution. Based on comparative genomics, the duplication of the… read more here.
Keywords: evolution; duplication; cenp; male germline ... See more keywords
Posttranslational mechanisms controlling centromere function and assembly.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in cell biology"
DOI: 10.1016/j.ceb.2018.03.003
Abstract: Accurate chromosome segregation is critical to ensure the faithful inheritance of the genome during cell division. Human chromosomes distinguish the location of the centromere from general chromatin by the selective assembly of CENP-A containing nucleosomes… read more here.
Keywords: controlling centromere; posttranslational mechanisms; cenp; centromere function ... See more keywords
Structure of the Human Core Centromeric Nucleosome Complex
Sign Up to like & getrecommendations! Published in 2019 at "Current Biology"
DOI: 10.1016/j.cub.2019.06.062
Abstract: Centromeric nucleosomes are at the interface of the chromosome and the kinetochore that connects to spindle microtubules in mitosis. The core centromeric nucleosome complex (CCNC) harbors the histone H3 variant, CENP-A, and its binding proteins, CENP-C… read more here.
Keywords: cenp; nucleosome complex; centromeric nucleosome; core centromeric ... See more keywords
Targeted De Novo Centromere Formation in Drosophila Reveals Plasticity and Maintenance Potential of CENP-A Chromatin.
Sign Up to like & getrecommendations! Published in 2020 at "Developmental cell"
DOI: 10.1016/j.devcel.2020.01.005
Abstract: Centromeres are essential for accurate chromosome segregation and are marked by centromere protein A (CENP-A) nucleosomes. Mis-targeted CENP-A chromatin has been shown to seed centromeres at non-centromeric DNA. However, the requirements for such de novo… read more here.
Keywords: drosophila; centromere formation; chromatin; novo centromere ... See more keywords
α-amino trimethylation of CENP-A by NRMT is required for full recruitment of the centromere
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14678
Abstract: Centromeres are unique chromosomal domains that control chromosome segregation, and are epigenetically specified by the presence of the CENP-A containing nucleosomes. CENP-A governs centromere function by recruiting the constitutive centromere associated network (CCAN) complex. The… read more here.
Keywords: cenp; amino trimethylation; trimethylation cenp; nrmt required ... See more keywords
The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-08314-x
Abstract: Centromeric nucleosomes are composed of the centromere-specific histone H3 variant CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore, histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism… read more here.
Keywords: targeting domain; cenp; cenp centromere; centromere targeting ... See more keywords
A non-canonical function for Centromere-associated protein-E controls centrosome integrity and orientation of cell division
Sign Up to like & getrecommendations! Published in 2021 at "Communications Biology"
DOI: 10.1038/s42003-021-01861-4
Abstract: Centromere-associated protein-E (CENP-E) is a kinesin motor localizing at kinetochores. Although its mitotic functions have been well studied, it has been challenging to investigate direct consequences of CENP-E removal using conventional methods because CENP-E depletion… read more here.
Keywords: associated protein; centromere associated; cenp; cell division ... See more keywords
Mechanism for G2 phase-specific nuclear export of the kinetochore protein CENP-F
Sign Up to like & getrecommendations! Published in 2017 at "Cell Cycle"
DOI: 10.1080/15384101.2017.1338218
Abstract: ABSTRACT Centromere protein F (CENP-F) is a component of the kinetochore and a regulator of cell cycle progression. CENP-F recruits the dynein transport machinery and orchestrates several cell cycle-specific transport events, including transport of the… read more here.
Keywords: export; phase; nuclear export; cell cycle ... See more keywords
A tension-independent mechanism reduces Aurora B-mediated phosphorylation upon microtubule capture by CENP-E at the kinetochore
Sign Up to like & getrecommendations! Published in 2019 at "Cell Cycle"
DOI: 10.1080/15384101.2019.1617615
Abstract: ABSTRACT During mitosis, Aurora B kinase is required for forming proper bi-oriented kinetochore-microtubule attachments. Current models suggest that tension exerted between a pair of sister-kinetochores (inter-kinetochore stretch) produces a spatial separation of Aurora B kinase… read more here.
Keywords: cenp; tension independent; tension; aurora mediated ... See more keywords
p97/VCP drives turnover of SUMOylated centromeric CCAN proteins and CENP-A.
Sign Up to like & getrecommendations! Published in 2023 at "Molecular biology of the cell"
DOI: 10.1091/mbc.e23-01-0035
Abstract: The centromere is a unique chromatin domain that links sister chromatids and forms the attachment site for spindle microtubules in mitosis. Centromere inheritance is largely DNA sequence-independent but strongly reliant on a self-propagating chromatin domain… read more here.
Keywords: centromeric cenp; p97 vcp; chromatin; ccan proteins ... See more keywords
Cdc48Ufd1/Npl4 segregase removes mislocalized centromeric histone H3 variant CENP-A from non-centromeric chromatin.
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic acids research"
DOI: 10.1093/nar/gkac135
Abstract: Restricting the localization of CENP-A (Cse4 in Saccharomyces cerevisiae) to centromeres prevents chromosomal instability (CIN). Mislocalization of overexpressed CENP-A to non-centromeric chromatin contributes to CIN in budding and fission yeasts, flies, and humans. Overexpression and… read more here.
Keywords: centromeric chromatin; cenp; cdc48ufd1 npl4; non centromeric ... See more keywords