A novel allele for inducible Cre expression in germinal center B cells
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Immunology"
DOI: 10.1002/eji.201847863
Abstract: The germinal center reaction is essential for efficient humoral immunity, but it can also give rise to B cell lymphomas. Cre/loxP‐mediated conditional gene knock‐out or knock‐in can be used for the genetic manipulation of germinal… read more here.
Keywords: germinal center; novel allele; allele inducible; inducible cre ... See more keywords
Heterogeneity of germinal center B cells: New insights from single-cell studies.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of immunology"
DOI: 10.1002/eji.202149235
Abstract: Upon antigen exposure, activated B cells in antigen-draining lymphoid organs form micro-anatomical structures, called germinal centers (GCs), where affinity maturation occurs. Within the GC microenvironment, GC B cells undergo proliferation and B cell receptor (BCR)… read more here.
Keywords: single cell; germinal center; affinity; center cells ... See more keywords
Germinal Center B Cells Replace Their Antigen Receptors in Dark Zones and Fail Light Zone Entry when Immunoglobulin Gene Mutations are Damaging
Sign Up to like & getrecommendations! Published in 2018 at "Immunity"
DOI: 10.1016/j.immuni.2018.08.025
Abstract: SUMMARY Adaptive immunity involves the development of bespoke antibodies in germinal centers (GCs) through immunoglobulin somatic hypermutation (SHM) in GC dark zones (DZs) and clonal selection in light zones (LZs). Accurate selection requires that cells… read more here.
Keywords: germinal center; dark zones; center cells; cells replace ... See more keywords
The AKT kinase signaling network is rewired by PTEN to control proximal BCR signaling in germinal center B cells
Sign Up to like & getrecommendations! Published in 2019 at "Nature immunology"
DOI: 10.1038/s41590-019-0376-3
Abstract: B cell antigen receptor (BCR) and CD40 signaling are rewired in germinal center (GC) B cells (GCBCs) to optimize selection for high-affinity B cells. In GCBC, BCR signals are constrained, but the mechanisms are not… read more here.
Keywords: germinal center; bcr; center cells; akt kinase ... See more keywords
Greater Breadth of Vaccine-Induced Immunity in Females than Males Is Mediated by Increased Antibody Diversity in Germinal Center B Cells
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DOI: 10.1128/mbio.01839-22
Abstract: Adult females develop greater antibody responses to influenza vaccines than males. We hypothesized that female-biased immunity and protection would be dependent on the extent of virus diversity as well as molecular mechanisms in B cells… read more here.
Keywords: maa cal; immunity; germinal center; center cells ... See more keywords
Gammaherpesvirus-infected germinal center cells express a distinct immunoglobulin repertoire
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DOI: 10.26508/lsa.201900526
Abstract: Germinal center B cells infected with gammaherpesvirus display altered repertoire with biased usage of lambda light chain and skewed utilization of IGHV genes. The gammaherpesviruses (γHVs), human Kaposi sarcoma-associated herpesvirus (KSHV), EBV, and murine γHV68… read more here.
Keywords: germinal center; hv68; center cells; repertoire ... See more keywords
Prolactin promotes proliferation of germinal center B cells, formation of plasma cells, and elevated levels of IgG3 anti-dsDNA autoantibodies
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.1017115
Abstract: Systemic lupus erythematosus (SLE) mainly affects females at reproductive age, which has been associated with hormones, such as prolactin (PRL). Different studies suggest that PRL exacerbates the clinical manifestations of SLE both in patients and… read more here.
Keywords: levels igg3; prl; proliferation germinal; center cells ... See more keywords
Distinctive High Expression of Antiretroviral APOBEC3 Protein in Mouse Germinal Center B Cells
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DOI: 10.3390/v14040832
Abstract: Tissue and subcellular localization and its changes upon cell activation of virus-restricting APOBEC3 at protein levels are important to understanding physiological functions of this cytidine deaminase, but have not been thoroughly analyzed in vivo. To… read more here.
Keywords: center cells; apobec3 protein; germinal center; levels apobec3 ... See more keywords
Germinal center B cells that acquire nuclear proteins are specifically suppressed by follicular regulatory T cells
Sign Up to like & getrecommendations! Published in 2023 at "eLife"
DOI: 10.7554/elife.83908
Abstract: Follicular regulatory T cells (Tfr) restrict development of autoantibodies and autoimmunity while supporting high-affinity foreign antigen-specific humoral response. However, whether Tfr can directly repress germinal center (GC) B cells that acquire autoantigens is unclear. Moreover,… read more here.
Keywords: regulatory cells; cells acquire; center cells; germinal center ... See more keywords