Detection of truncated isoforms of human neuroserpin lacking the reactive center loop: Implications in noninhibitory role
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DOI: 10.1002/iub.2475
Abstract: Neuroserpin is a serine protease inhibitor expressed mainly in the brain and at low levels in other tissues like the kidney, testis, heart, and spinal cord. It is involved in the inhibition of tissue plasminogen… read more here.
Keywords: human neuroserpin; isoforms human; role; center loop ... See more keywords
Reactive Center Loop Insertion in α-1-Antitrypsin Captured by Accelerated Molecular Dynamics Simulation.
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DOI: 10.1021/acs.biochem.6b00839
Abstract: Protease inhibition by metastable serine protease inhibitors (serpins) is mediated by one of the largest functional intradomain conformational changes known in biology. In this extensive structural rearrangement, protease-serpin complex formation triggers cleavage of the serpin… read more here.
Keywords: molecular dynamics; insertion; accelerated molecular; center loop ... See more keywords