B Cell-Intrinsic Expression of Interferon Regulatory Factor 1 Supports Chronic Murine Gammaherpesvirus 68 Infection
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DOI: 10.1128/jvi.00399-20
Abstract: Gammaherpesviruses establish lifelong infection in over 95% of all adults and are associated with B cell lymphomas. The virus’s manipulation of the germinal center response and B cell differentiation to establish lifelong infection is thought… read more here.
Keywords: germinal center; infection; cell; center response ... See more keywords
T Cell-Intrinsic Interleukin 17 Receptor A Signaling Supports the Establishment of Chronic Murine Gammaherpesvirus 68 Infection
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DOI: 10.1128/jvi.00639-22
Abstract: Gammaherpesviruses, such as human EBV, establish lifelong infection in >95% of adults and are associated with B cell lymphomas. Gammaherpesviruses usurp the germinal center response to establish latent infection, and the germinal center B cells… read more here.
Keywords: center response; cell; infection; 17ra signaling ... See more keywords
A multiscale spatial modeling framework for the germinal center response
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DOI: 10.3389/fimmu.2024.1377303
Abstract: The germinal center response or reaction (GCR) is a hallmark event of adaptive humoral immunity. Unfolding in the B cell follicles of the secondary lymphoid organs, a GC culminates in the production of high-affinity antibody-secreting… read more here.
Keywords: framework; response; cell; center response ... See more keywords