Isolated Central Adrenal Insufficiency Due to Nivolumab: A Case Report
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DOI: 10.1210/jendso/bvab048.1204
Abstract: Abstract Background: Immune checkpoint inhibitors are immunomodulatory antibodies directed against programmed cell death 1 (PD-1), Nivolumab, or cytotoxic T-lymphocyte antigen-4 (CTLA-4) Ipilimumab. They have improved outcomes in patients with advanced cancers including renal cell carcinoma,… read more here.
Keywords: central adrenal; adrenal insufficiency; isolated central; case ... See more keywords
Multimodal Regulation of Circadian Glucocorticoid Rhythm by Central and Adrenal Clocks
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DOI: 10.1210/js.2018-00021
Abstract: Abstract Adrenal glucocorticoids (GCs) control a wide range of physiological processes, including metabolism, cardiovascular and pulmonary activities, immune and inflammatory responses, and various brain functions. During stress responses, GCs are secreted through activation of the… read more here.
Keywords: regulation circadian; glucocorticoid rhythm; central adrenal; multimodal regulation ... See more keywords
SAT-446 No Central Adrenal Insufficiency Found in Adults with Prader-Willi Syndrome Tested by Multiple-Dose Metyrapone Test
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DOI: 10.1210/js.2019-sat-446
Abstract: Abstract Introduction Individuals with Prader-Willi syndrome (PWS) have hypothalamic dysfunction, with deficiencies of several hypothalamic-pituitary axes. Prevalence of central hypogonadism, hypothyroidism and growth hormone deficiency are increased in comparison with non-PWS individuals. Central adrenal insufficiency… read more here.
Keywords: adrenal insufficiency; test; central adrenal; prader willi ... See more keywords
Performance of glucagon stimulation test in diagnosing central adrenal insufficiency in children when utilising the Roche Elecsys® cortisol II assay: a pilot study
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DOI: 10.1515/jpem-2022-0252
Abstract: Abstract Objectives The glucagon stimulation test (GST) is used for the simultaneous assessment of central adrenal insufficiency (CAI) and growth hormone deficiency. The new Roche cortisol II (C II) assay was recently introduced, confounding interpretation… read more here.
Keywords: gst; test; cortisol; adrenal insufficiency ... See more keywords
Central adrenal insufficiency: who, when, and how? From the evidence to the controversies - an exploratory review.
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DOI: 10.20945/2359-3997000000493
Abstract: Central adrenal insufficiency (CAI) is a life-threatening disorder. This occurs when ACTH production is insufficient, leading to low cortisol levels. Since corticosteroids are crucial to many metabolic responses under organic stress and inflammatory conditions, CAI… read more here.
Keywords: insufficiency evidence; controversies exploratory; evidence controversies; adrenal insufficiency ... See more keywords