A Central-to-Axial Chirality Conversion Strategy for the Synthesis of C-N Axially Chiral N-Arylpyrroles.
Sign Up to like & getrecommendations! Published in 2022 at "Organic letters"
DOI: 10.1021/acs.orglett.2c00753
Abstract: We present a central-to-axial chirality conversion strategy for the construction of C-N axially chiral N-arylpyrroles via a gold(I)-catalyzed 5-endo-dig cyclization/dehydration cascade from amino acid derivatives. The reaction exhibits high efficiency on the central-to-axial chirality conversion.… read more here.
Keywords: axial chirality; conversion strategy; chirality conversion; central axial ... See more keywords
Asymmetric allylic substitution–isomerization to axially chiral enamides via hydrogen-bonding assisted central-to-axial chirality transfer†
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DOI: 10.1039/d0sc02828b
Abstract: Axially chiral enamides bearing a N–C axis have been recently studied and were proposed to be valuable chiral building blocks, but a stereoselective synthesis has not been achieved. Here, we report the first enantioselective synthesis… read more here.
Keywords: enamides via; central axial; transfer; chiral enamides ... See more keywords
HPLC Enantioseparation of Rigid Chiral Probes with Central, Axial, Helical, and Planar Stereogenicity on an Amylose (3,5-Dimethylphenylcarbamate) Chiral Stationary Phase
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DOI: 10.3390/molecules27238527
Abstract: The chiral resolving ability of the commercially available amylose (3,5-dimethylphenylcarbamate)-based chiral stationary phase (CSP) toward four chiral probes representative of four kinds of stereogenicity (central, axial, helical, and planar) was investigated. Besides chirality, the evident… read more here.
Keywords: stationary phase; chiral probes; central axial; amylose dimethylphenylcarbamate ... See more keywords
Enantioselective Synthesis of Atropisomers by Oxidative Aromatization with Central-to-Axial Conversion of Chirality
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DOI: 10.3390/molecules28073142
Abstract: Atropisomers are fascinating objects of study by themselves for chemists but also find applications in various sub-fields of applied chemistry. Obtaining them in enantiopure form is far from being a solved challenge, and the past… read more here.
Keywords: oxidative aromatization; aromatization central; conversion chirality; central axial ... See more keywords