Allosteric Effectors Outcompete Transcript Levels and Substrate Concentration in Regulating Central Carbon Flux During the Crabtree Effect Transition
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DOI: 10.1002/biot.70024
Abstract: While the metabolic shift in Saccharomyces cerevisiae across the Crabtree effect is well‐documented, the role of allosteric regulation in this transition remains unclear. Here, we investigated allosteric regulation by inducing a growth rate shift from… read more here.
Keywords: allosteric effectors; crabtree effect; transition; central carbon ... See more keywords
Time-scale dynamics of proteome predicts the central carbon metabolism involved in triterpenoid accumulation responsive to nitrogen limitation in Ganoderma lucidum.
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DOI: 10.1016/j.funbio.2020.11.009
Abstract: Central carbon metabolism describes the integration of transport pathway of main carbon sources inside the cell. Nitrogen (N) limitation is a favorable approach to stimulate ganoderic triterpenoid (GT) accumulation in Ganoderma lucidum. In this study, the… read more here.
Keywords: carbon; limitation; central carbon; lucidum ... See more keywords
Microbial central carbon metabolism in a tidal freshwater marsh and an upland mixed conifer soil under oxic and anoxic conditions
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DOI: 10.1128/aem.00724-24
Abstract: ABSTRACT The central carbon (C) metabolic network is responsible for most of the production of energy and biosynthesis in microorganisms and is therefore key to a mechanistic understanding of microbial life in soil communities. Many… read more here.
Keywords: oxygen; upland soil; marsh; soil ... See more keywords
Probing the core metabolism of Cereibacter sphaeroides by transposon mutagenesis
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DOI: 10.1128/jb.00306-25
Abstract: ABSTRACT During phototrophic growth, Cereibacter sphaeroides can use several carbon substrates that are central carbon intermediates (e.g., succinate and L-malate) or that require only a few steps to enter central carbon metabolism (e.g., acetate and… read more here.
Keywords: cereibacter sphaeroides; carbon; metabolism; central carbon ... See more keywords
Central Carbon Metabolism Regulates Macrophage Antitumor Activity.
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DOI: 10.1158/2159-8290.cd-rw2019-015
Abstract: CpG rewires macrophage metabolism to bypass inhibitory CD47 signals and enhance antitumor activity. read more here.
Keywords: central carbon; antitumor activity; metabolism; carbon metabolism ... See more keywords
Prognostic Roles of Central Carbon Metabolism–Associated Genes in Patients With Low-Grade Glioma
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DOI: 10.3389/fgene.2019.00831
Abstract: Purpose: Metabolic alterations are crucial for tumor progression and response to therapy. The comprehensive model of combined central carbon metabolism–associated genes that contribute to the outcomes of glioma and astrocytoma is not well understood. Method:… read more here.
Keywords: metabolism associated; metabolism; central carbon; carbon metabolism ... See more keywords
The differing responses of central carbon cycle metabolism in male and female Sargassum thunbergii to ultraviolet-B radiation
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DOI: 10.3389/fpls.2022.904943
Abstract: The enhancement of ultraviolet-B radiation (UV-B) radiation reaching the Earth’s surface due to ozone layer depletion is an important topic. Macroalgal species growing in the intertidal zone are often directly exposed to UV-B radiation periodically… read more here.
Keywords: carbon; sargassum thunbergii; ultraviolet radiation; radiation ... See more keywords
Central Carbon Metabolism in Candida albicans Biofilms Is Altered by Dimethyl Sulfoxide
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DOI: 10.3390/jof10050337
Abstract: The effect of dimethyl sulfoxide (DMSO) on fungal metabolism has not been well studied. This study aimed to evaluate, by metabolomics, the impact of DMSO on the central carbon metabolism of Candida albicans. Biofilms of… read more here.
Keywords: metabolism candida; candida albicans; metabolism; carbon metabolism ... See more keywords
Lactucin, a Bitter Sesquiterpene from Cichorium intybus, Inhibits Cancer Cell Proliferation by Downregulating the MAPK and Central Carbon Metabolism Pathway
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DOI: 10.3390/molecules27217358
Abstract: Lung cancer, especially adenocarcinoma, is the second most occurring and highest fatality-causing cancer worldwide. Many natural anticancer compounds, such as sesquiterpene lactones (SLs), show promising anticancer properties. Herein, we examined Lactucin, an SL from the… read more here.
Keywords: cell; proliferation; carbon metabolism; central carbon ... See more keywords
Regulation of Central Carbon and Amino Acid Metabolism in Plants
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DOI: 10.3390/plants10030430
Abstract: Fluctuations in the prevailing environmental conditions, including light availability and intensity, CO2/O2 ratio, temperature, and nutrient or water supply, require rapid metabolic switches to maintain proper metabolism [...]. read more here.
Keywords: metabolism; metabolism plants; central carbon; carbon amino ... See more keywords