Location of contact residues in pharmacologically distinct drug binding sites on P‐glycoprotein
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.10.002
Abstract: Graphical abstract Figure. No Caption available. Abstract The multidrug resistance P‐glycoprotein (P‐gp) is characterised by the ability to bind and/or transport an astonishing array of drugs. This poly‐specificity is imparted by at least four pharmacologically… read more here.
Keywords: drug binding; central cavity; contact residues; pharmacologically distinct ... See more keywords
Structural effect on the central cavity of a pendent 12N3 macrocycle on bonding and photophysical properties of Eu3+ and Tb3+ complexes: Experimental and theoretical study
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Molecular Structure"
DOI: 10.1016/j.molstruc.2019.02.032
Abstract: Abstract The effect of the ring size of the central cavity of a triaza macrocycle on coordination, bonding and properties is described through synthesis, characterization and detailed DFT studies. For this, two new Eu3+ and… read more here.
Keywords: central cavity; ligand; eu3 tb3; geometry ... See more keywords
8-Oxoguanine Forms Quartets with a Large Central Cavity
Sign Up to like & getrecommendations! Published in 2022 at "Biochemistry"
DOI: 10.1021/acs.biochem.2c00478
Abstract: Oxidation of a guanine nucleotide in DNA yields an 8-oxoguanine nucleotide (oxoG) and is a mutagenic event in the genome. Due to different arrangements of hydrogen-bond donors and acceptors, oxoG can affect the secondary structure… read more here.
Keywords: cavity; central cavity; oxoguanine forms; quartets large ... See more keywords
The interaction between transport-segment DNA and topoisomerase IA—crystal structure of MtbTOP1 in complex with both G- and T-segments
Sign Up to like & getrecommendations! Published in 2022 at "Nucleic Acids Research"
DOI: 10.1093/nar/gkac1205
Abstract: Abstract Each catalytic cycle of type IA topoisomerases has been proposed to comprise multistep reactions. The capture of the transport-segment DNA (T-segment) into the central cavity of the N-terminal toroidal structure is an important action,… read more here.
Keywords: central cavity; segment dna; dna; topoisomerase ... See more keywords
Cryo-EM Structures of AcrD Illuminate a Mechanism for Capturing Aminoglycosides from Its Central Cavity
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DOI: 10.1128/mbio.03383-22
Abstract: Here, we report cryo-EM structures of the AcrD aminoglycoside efflux pump in the absence and presence of bound gentamicin, posing the possibility that this pump is capable of capturing aminoglycosides from the central cavity of… read more here.
Keywords: cavity; central cavity; cryo structures; structures acrd ... See more keywords