RETRACTED: Genetically reducing mTOR signaling rescues central insulin dysregulation in a mouse model of Alzheimer's disease
Sign Up to like & getrecommendations! Published in 2018 at "Neurobiology of Aging"
DOI: 10.1016/j.neurobiolaging.2018.03.032
Abstract: Alzheimer's disease (AD) is the most common neurodegenerative disease. The causes of sporadic AD, which represents more than 95% of AD cases, are unknown. Several AD risk factors have been identified and among these, type… read more here.
Keywords: central insulin; alzheimer disease; mtor signaling; mtor ... See more keywords
Effects of acute olanzapine exposure on central insulin-mediated regulation of whole body fuel selection and feeding
Sign Up to like & getrecommendations! Published in 2018 at "Psychoneuroendocrinology"
DOI: 10.1016/j.psyneuen.2018.07.028
Abstract: The use of antipsychotics is associated with severe disruptions in whole body glucose and lipid metabolism which may in part occur through the central nervous system and impaired insulin action at the brain. Here we… read more here.
Keywords: insulin; rer; central insulin; icv insulin ... See more keywords
Falling Short: The Contribution of Central Insulin Receptors to Gait Dysregulation in Brain Aging
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10081923
Abstract: Insulin resistance, which manifests as a reduction of insulin receptor signaling, is known to correlate with pathological changes in peripheral tissues as well as in the brain. Central insulin resistance has been associated with impaired… read more here.
Keywords: insulin resistance; brain; central insulin; gait dysregulation ... See more keywords
Ocular manifestations of central insulin resistance
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.355765
Abstract: Central insulin resistance, the diminished cellular sensitivity to insulin in the brain, has been implicated in diabetes mellitus, Alzheimer’s disease and other neurological disorders. However, whether and how central insulin resistance plays a role in… read more here.
Keywords: optic nerve; insulin resistance; central insulin; insulin signaling ... See more keywords