Olanzapine-induced insulin resistance may occur via attenuation of central KATP channel-activation
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DOI: 10.1016/j.schres.2020.12.005
Abstract: Antipsychotic use is associated with an increased risk of type 2 diabetes. Recent work suggests antipsychotics can induce insulin resistance immediately and independently of weight gain, and that this may occur via the central nervous… read more here.
Keywords: katp channel; channel; channel activation; olanzapine ... See more keywords
Central KATP Channels Modulate Glucose Effectiveness in Humans and Rodents
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DOI: 10.2337/db19-1256
Abstract: Hyperglycemia is a potent regulator of endogenous glucose production (EGP). Loss of this “glucose effectiveness” is a major contributor to elevated plasma glucose concentrations in type 2 diabetes (T2D). KATP channels in the central nervous… read more here.
Keywords: glucose effectiveness; katp channels; katp; hyperglycemia ... See more keywords