Live-cell imaging reveals the relative contributions of antigen-presenting cell subsets to thymic central tolerance
Sign Up to like & getrecommendations! Published in 2019 at "Nature Communications"
DOI: 10.1038/s41467-019-09727-4
Abstract: Both medullary thymic epithelial cells (mTEC) and dendritic cells (DC) present tissue-restricted antigens (TRA) to thymocytes to induce central tolerance, but the relative contributions of these antigen-presenting cell (APC) subsets remain unresolved. Here we developed… read more here.
Keywords: central tolerance; relative contributions; tolerance; contributions antigen ... See more keywords
Absence of central tolerance in Aire-deficient mice synergizes with immune-checkpoint inhibition to enhance antitumor responses
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DOI: 10.1038/s42003-020-1083-1
Abstract: The endogenous anti-tumor responses are limited in part by the absence of tumor-reactive T cells, an inevitable consequence of thymic central tolerance mechanisms ensuring prevention of autoimmunity. Here we show that tumor rejection induced by… read more here.
Keywords: immune checkpoint; central tolerance; anti tumor; mice ... See more keywords
Central tolerance promoted by cell chimerism
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2214989119
Abstract: Historically, successful allotransplantation was only achieved by utilizing powerful immunosuppressive drugs that were exposing the patient to severe opportunistic infections. The thymus of the transplant recipient renders such therapy obligatory as it constitutively blocks self-reactive… read more here.
Keywords: tolerance promoted; cell; chimerism; donor ... See more keywords
CTLA-4 on thymic epithelial cells complements Aire for T cell central tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2215474119
Abstract: Significance We found that the immunoregulatory receptor CTLA-4 is expressed on mTECs, where it mediates T cell central tolerance. This work deepens our understanding of how T cell tolerance is established and autoimmunity can arise… read more here.
Keywords: thymic epithelial; cell central; ctla thymic; tolerance ... See more keywords
Central tolerance is impaired in the middle‐aged thymic environment
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DOI: 10.1111/acel.13624
Abstract: One of the earliest hallmarks of immune aging is thymus involution, which not only reduces the number of newly generated and exported T cells, but also alters the composition and organization of the thymic microenvironment.… read more here.
Keywords: central tolerance; aged thymic; thymic environment; tolerance ... See more keywords
B‐cell intrinsic and extrinsic signals that regulate central tolerance of mouse and human B cells *
Sign Up to like & getrecommendations! Published in 2022 at "Immunological Reviews"
DOI: 10.1111/imr.13062
Abstract: The random recombination of immunoglobulin V(D)J gene segments produces unique IgM antibodies that serve as the antigen receptor for each developing B cell. Hence, the newly formed B cell repertoire is comprised of a variety… read more here.
Keywords: cell; self antigen; mouse human; central tolerance ... See more keywords
The adaptation model of immunity: Is the goal of central tolerance to eliminate defective T cells or self‐reactive T cells?
Sign Up to like & getrecommendations! Published in 2022 at "Scandinavian Journal of Immunology"
DOI: 10.1111/sji.13209
Abstract: The self‐non‐self model and the danger model are designed to understand how an immune response is induced. These models are not meant to predict if an immune response may succeed or fail in destroying/controlling its… read more here.
Keywords: self reactive; cells self; central tolerance; defective cells ... See more keywords
Analysis of a miR-148a Targetome in B Cell Central Tolerance
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.861655
Abstract: A microRNA (miRNA) often regulates the expression of hundreds of target genes. A fundamental question in the field of miRNA research is whether a miRNA exerts its biological function through regulating a small number of… read more here.
Keywords: cell central; mir 148a; target genes; central tolerance ... See more keywords
Genetic Modifiers of Thymic Selection and Central Tolerance in Type 1 Diabetes
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DOI: 10.3389/fimmu.2022.889856
Abstract: Type 1 diabetes (T1D) is caused by the T cell-driven autoimmune destruction of insulin-producing cells in the pancreas. T1D served as the prototypical autoimmune disease for genome wide association studies (GWAS) after having already been… read more here.
Keywords: central tolerance; thymic selection; tolerance; type diabetes ... See more keywords