Mutations in the palm domain disrupt modulation of acid-sensing ion channel 1a currents by neuropeptides
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DOI: 10.1038/s41598-018-37426-5
Abstract: Modulation by neuropeptides enhances several functions of acid-sensing ion channels (ASICs), such as pain sensation and acid-induced neuronal injury. The acid-induced opening of ASICs is transient, because of a rapid desensitization. Neuropeptides containing an Arg-Phe-amide… read more here.
Keywords: central vestibule; modulation; sensing ion; domain ... See more keywords