EZH2 enables germinal centre formation through epigenetic silencing of CDKN1A and an Rb-E2F1 feedback loop
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DOI: 10.1038/s41467-017-01029-x
Abstract: The EZH2 histone methyltransferase is required for B cells to form germinal centers (GC). Here we show that EZH2 mediates GC formation through repression of cyclin-dependent kinase inhibitor CDKN1A (p21Cip1). Deletion of Cdkn1a rescues the… read more here.
Keywords: cdkn1a; feedback loop; ezh2; germinal centre ... See more keywords