The centriolar satellite protein CCDC66 interacts with CEP290 and functions in cilium formation and trafficking
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DOI: 10.1242/jcs.196832
Abstract: ABSTRACT Centriolar satellites are membrane-less structures that localize and move around the centrosome and cilium complex in a microtubule-dependent manner. They play important roles in centrosome- and cilium-related processes, including protein trafficking to the centrosome… read more here.
Keywords: protein; centriolar satellite; cilium; ccdc66 ... See more keywords
Centriolar satellite biogenesis and function in vertebrate cells
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DOI: 10.1242/jcs.239566
Abstract: ABSTRACT Centriolar satellites are non-membranous cytoplasmic granules that concentrate in the vicinity of the centrosome, the major microtubule-organizing centre (MTOC) in animal cells. Originally assigned as conduits for the transport of proteins towards the centrosome… read more here.
Keywords: function; satellite biogenesis; biogenesis function; centriolar satellite ... See more keywords
EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole.
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DOI: 10.15252/embr.202256317
Abstract: Primary cilia are sensory organelles that coordinate diverse signaling pathways, controlling development and homeostasis. Progression beyond the early steps of ciliogenesis requires the removal of a distal end protein, CP110, from the mother centriole, a… read more here.
Keywords: herc2; ciliogenesis; mother centriole; cp110 ubiquitination ... See more keywords