Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.1101/2022.04.04.486992
Abstract: Centrosomes are orbited by centriolar satellites, dynamic multiprotein assemblies nucleated by PCM1. To study the requirement for centriolar satellites, we generated mice lacking PCM1. Pcm1−/− mice display partially penetrant perinatal lethality with survivors exhibiting hydrocephalus,… read more here.
Keywords: ciliogenesis; centriolar satellites; mother centriole; expedite mother ... See more keywords
Centriolar satellites are required for efficient ciliogenesis and ciliary content regulation
Sign Up to like & getrecommendations! Published in 2019 at "EMBO Reports"
DOI: 10.15252/embr.201947723
Abstract: Centriolar satellites are ubiquitous in vertebrate cells. They have recently emerged as key regulators of centrosome/cilium biogenesis, and their mutations are linked to ciliopathies. However, their precise functions and mechanisms of action remain poorly understood.… read more here.
Keywords: ciliogenesis; centriolar satellites; lacking satellites; ciliary content ... See more keywords