Phosphorylation of keratin 18 serine 52 regulates mother–daughter centriole engagement and microtubule nucleation by cell cycle-dependent accumulation at the centriole
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DOI: 10.1007/s00418-020-01849-x
Abstract: Serine-52 (Ser52) is the major physiologic site of keratin 18 (K18) phosphorylation. Here, we report that serine-52 phosphorylated K18 (phospho-Ser52 K18) accumulated on centrosomes in a cell cycle-dependent manner. Moreover, we found that phospho-Ser52 K18… read more here.
Keywords: cell cycle; phospho ser52; ser52; ser52 k18 ... See more keywords
Direct binding of CEP85 to STIL ensures robust PLK4 activation and efficient centriole assembly
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DOI: 10.1038/s41467-018-04122-x
Abstract: Centrosomes are required for faithful chromosome segregation during mitosis. They are composed of a centriole pair that recruits and organizes the microtubule-nucleating pericentriolar material. Centriole duplication is tightly controlled in vivo and aberrations in this… read more here.
Keywords: centriole assembly; plk4 activation; centriole;
A novel atypical sperm centriole is functional during human fertilization
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DOI: 10.1038/s41467-018-04678-8
Abstract: The inheritance of the centrosome during human fertilization remains mysterious. Here we show that the sperm centrosome contains, in addition to the known typical barrel-shaped centriole (the proximal centriole, PC), a surrounding matrix (pericentriolar material,… read more here.
Keywords: novel atypical; atypical sperm; atypical centriole; human fertilization ... See more keywords
Centriole assembly at a glance
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DOI: 10.1242/jcs.228833
Abstract: ABSTRACT The centriole organelle consists of microtubules (MTs) that exhibit a striking 9-fold radial symmetry. Centrioles play fundamental roles across eukaryotes, notably in cell signaling, motility and division. In this Cell Science at a Glance… read more here.
Keywords: centriole assembly; cell science; assembly glance; glance ... See more keywords
MICAL-L1 coordinates ciliogenesis by recruiting EHD1 to the primary cilium
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DOI: 10.1242/jcs.233973
Abstract: ABSTRACT The endocytic protein EHD1 plays an important role in ciliogenesis by facilitating fusion of the ciliary vesicle and removal of CP110 (also known as CCP110) from the mother centriole, as well as removal of… read more here.
Keywords: ciliogenesis; ehd1; tubulin tubulin; interaction ... See more keywords