Histone Deacetylase SIRT1 Targets Plk2 to Regulate Centriole Duplication.
Sign Up to like & getrecommendations! Published in 2018 at "Cell reports"
DOI: 10.1016/j.celrep.2018.11.025
Abstract: The protein deacetylase SIRT1 (Sirtuin 1) regulates many cellular processes, including cell-cycle progression, DNA damage response, and metabolism. Although the centrosome is a key regulator of cell-cycle progression and genome stability, little is known concerning… read more here.
Keywords: sirt1; deacetylase sirt1; centriole duplication; plk2 ... See more keywords
The dimeric Golgi protein Gorab binds to Sas6 as a monomer to mediate centriole duplication
Sign Up to like & getrecommendations! Published in 2021 at "eLife"
DOI: 10.7554/elife.57241
Abstract: The duplication and ninefold symmetry of the Drosophila centriole requires that the cartwheel molecule, Sas6, physically associates with Gorab, a trans-Golgi component. How Gorab achieves these disparate associations is unclear. Here, we use hydrogen–deuterium exchange… read more here.
Keywords: centriole duplication; monomer; gorab; sas6 ... See more keywords
Alstrom syndrome gene is a stem-cell-specific regulator of centriole duplication in the Drosophila testis
Sign Up to like & getrecommendations! Published in 2020 at "eLife"
DOI: 10.7554/elife.59368
Abstract: Asymmetrically dividing stem cells often show asymmetric behavior of the mother versus daughter centrosomes, whereby the self-renewing stem cell selectively inherits the mother or daughter centrosome. Although the asymmetric centrosome behavior is widely conserved, its… read more here.
Keywords: stem cell; centriole duplication; cell specific; alstrom syndrome ... See more keywords