Loss of Centromere Cohesion in Aneuploid Human Oocytes Correlates with Decreased Kinetochore Localization of the Sac Proteins Bub1 and Bubr1
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DOI: 10.1038/srep44001
Abstract: In human eggs, aneuploidy increases with age and can result in infertility and genetic diseases. Studies in mouse oocytes suggest that reduced centromere cohesion and spindle assembly checkpoint (SAC) activity could be at the origin… read more here.
Keywords: bub1 bubr1; centromere cohesion; human oocytes; sac ... See more keywords
A kinase‐dependent role for Haspin in antagonizing Wapl and protecting mitotic centromere cohesion
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DOI: 10.15252/embr.201744737
Abstract: Sister‐chromatid cohesion mediated by the cohesin complex is fundamental for precise chromosome segregation in mitosis. Through binding the cohesin subunit Pds5, Wapl releases the bulk of cohesin from chromosome arms in prophase, whereas centromeric cohesin… read more here.
Keywords: cohesin; centromere cohesion; cohesion; kinase dependent ... See more keywords