The CENP-A centromere targeting domain facilitates H4K20 monomethylation in the nucleosome by structural polymorphism
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DOI: 10.1038/s41467-019-08314-x
Abstract: Centromeric nucleosomes are composed of the centromere-specific histone H3 variant CENP-A and the core histones H2A, H2B, and H4. To establish a functional kinetochore, histone H4 lysine-20 (H4K20) must be monomethylated, but the underlying mechanism… read more here.
Keywords: targeting domain; cenp; cenp centromere; centromere targeting ... See more keywords