Centrosome-derived microtubule radial array, PCM-1 protein, and primary cilia formation.
Sign Up to like & getrecommendations! Published in 2019 at "Protoplasma"
DOI: 10.1007/s00709-019-01385-z
Abstract: In animal cells, the centrosome nucleates and anchors microtubules (MT), forming their radial array. During interphase centrosome-derived MT, aster can either team up with other MT network or function in an autonomous manner. What is… read more here.
Keywords: centrosome; formation; pcm; centrosome derived ... See more keywords
Spatial centrosome proteome of human neural cells uncovers disease-relevant heterogeneity
Sign Up to like & getrecommendations! Published in 2022 at "Science"
DOI: 10.1126/science.abf9088
Abstract: The centrosome provides an intracellular anchor for the cytoskeleton, regulating cell division, cell migration, and cilia formation. We used spatial proteomics to elucidate protein interaction networks at the centrosome of human induced pluripotent stem cell–derived… read more here.
Keywords: cell; stem cell; neural stem; centrosome ... See more keywords
Impaired Reorganization of Centrosome Structure Underlies Human Infantile Dilated Cardiomyopathy
Sign Up to like & getrecommendations! Published in 2023 at "Circulation"
DOI: 10.1161/circulationaha.122.060985
Abstract: Background: During cardiomyocyte maturation, the centrosome, which functions as a microtubule organizing center in cardiomyocytes, undergoes dramatic structural reorganization where its components reorganize from being localized at the centriole to the nuclear envelope. This developmentally… read more here.
Keywords: reorganization; structure; idcm; gene ... See more keywords
A catalog of numerical centrosome defects in epithelial ovarian cancers
Sign Up to like & getrecommendations! Published in 2022 at "EMBO Molecular Medicine"
DOI: 10.15252/emmm.202215670
Abstract: Centrosome amplification, the presence of more than two centrosomes in a cell is a common feature of most human cancer cell lines. However, little is known about centrosome numbers in human cancers and whether amplification… read more here.
Keywords: catalog numerical; epithelial ovarian; ovarian cancers; centrosome amplification ... See more keywords
Inflammasome Meets Centrosome: Understanding the Emerging Role of Centrosome in Controlling Inflammasome Activation
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.826106
Abstract: Inflammasomes are multi-protein platforms that are assembled in response to microbial and danger signals to activate proinflammatory caspase-1 for production of active form of IL-1β and induction of pyroptotic cell death. Where and how an… read more here.
Keywords: controlling inflammasome; centrosome; activation; meets centrosome ... See more keywords
Centrosome Dynamics and Its Role in Inflammatory Response and Metastatic Process
Sign Up to like & getrecommendations! Published in 2021 at "Biomolecules"
DOI: 10.3390/biom11050629
Abstract: Metastasis is a process by which cancer cells escape from the location of the primary tumor invading normal tissues at distant organs. Chromosomal instability (CIN) is a hallmark of human cancer, associated with metastasis and… read more here.
Keywords: role inflammatory; dynamics role; centrosome dynamics; process ... See more keywords