Centrosome amplification mediates small extracellular vesicle secretion via lysosome disruption
Sign Up to like & getrecommendations! Published in 2021 at "Current Biology"
DOI: 10.1016/j.cub.2021.01.028
Abstract: Summary Bidirectional communication between cells and their surrounding environment is critical in both normal and pathological settings. Extracellular vesicles (EVs), which facilitate the horizontal transfer of molecules between cells, are recognized as an important constituent… read more here.
Keywords: extracellular vesicle; secretion; cancer; centrosome amplification ... See more keywords
Epstein–Barr virus particles induce centrosome amplification and chromosomal instability
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/ncomms14257
Abstract: Infections with Epstein–Barr virus (EBV) are associated with cancer development, and EBV lytic replication (the process that generates virus progeny) is a strong risk factor for some cancer types. Here we report that EBV infection… read more here.
Keywords: epstein barr; chromosomal instability; centrosome amplification; virus ... See more keywords
Oncogenic PIK3CA induces centrosome amplification and tolerance to genome doubling
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-02002-4
Abstract: Mutations in PIK3CA are very frequent in cancer and lead to sustained PI3K pathway activation. The impact of acute expression of mutant PIK3CA during early stages of malignancy is unknown. Using a mouse model to… read more here.
Keywords: tolerance; genome doubling; induces centrosome; genome ... See more keywords
Prognostic value of CA20, a score based on centrosome amplification-associated genes, in breast tumors
Sign Up to like & getrecommendations! Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-00363-w
Abstract: Centrosome amplification (CA) is a hallmark of cancer, observable in ≥75% of breast tumors. CA drives aggressive cellular phenotypes such as chromosomal instability (CIN) and invasiveness. Thus, assessment of CA may offer insights into the… read more here.
Keywords: ca20; breast tumors; prognostic value; ca20 score ... See more keywords
The Chlamydia trachomatis type III-secreted effector protein CteG induces centrosome amplification through interactions with centrin-2
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2303487120
Abstract: The centrosome is the main microtubule organizing center of the cell and is crucial for mitotic spindle assembly, chromosome segregation, and cell division. Centrosome duplication is tightly controlled, yet several pathogens, most notably oncogenic viruses,… read more here.
Keywords: effector protein; chlamydia trachomatis; amplification; physiology ... See more keywords
Centriole splitting caused by loss of the centrosomal linker protein C-NAP1 reduces centriolar satellite density and impedes centrosome amplification
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e16-05-0325
Abstract: Knockout of the centriolar linker C-NAP1 increased centriole separation and dispersed centriolar satellites. Primary cilia formed normally, even though the ciliary rootlet was mislocalized, and mechanosensory ciliary signaling was intact. Reduced levels of centrosome amplification… read more here.
Keywords: splitting caused; centrosome amplification; linker; centriole splitting ... See more keywords
The variant senescence‐associated secretory phenotype induced by centrosome amplification constitutes a pathway that activates hypoxia‐inducible factor‐1α
Sign Up to like & getrecommendations! Published in 2023 at "Aging Cell"
DOI: 10.1111/acel.13766
Abstract: The senescence‐associated secretory phenotype (SASP) can promote paracrine invasion while suppressing tumour growth, thus generating complex phenotypic outcomes. Likewise, centrosome amplification can induce proliferation arrest yet also facilitate tumour invasion. However, the eventual fate of… read more here.
Keywords: secretory phenotype; associated secretory; amplification; centrosome amplification ... See more keywords
BRCA1 transports the DNA damage signal for CDDP‐induced centrosome amplification through the centrosomal Aurora A
Sign Up to like & getrecommendations! Published in 2022 at "Cancer Science"
DOI: 10.1111/cas.15573
Abstract: Breast cancer gene 1 (BRCA1) plays roles in DNA repair and centrosome regulation and is involved in DNA damage‐induced centrosome amplification (DDICA). Here, the centrosomal localization of BRCA1 and the kinases involved in centrosome duplication… read more here.
Keywords: brca1; dna damage; cddp; centrosome amplification ... See more keywords
Chlamydia and HPV induce centrosome amplification in the host cell through additive mechanisms.
Sign Up to like & getrecommendations! Published in 2021 at "Cellular microbiology"
DOI: 10.1111/cmi.13397
Abstract: Based on epidemiology studies, Chlamydia trachomatis has been proposed as a co-factor for human papillomavirus (HPV) in the development of cervical cancer. These two intracellular pathogens have been independently reported to induce the production of… read more here.
Keywords: host cell; centrosome amplification; amplification; chlamydia hpv ... See more keywords
Proteomic mapping and targeting of mitotic pericentriolar material in tumors bearing centrosome amplification.
Sign Up to like & getrecommendations! Published in 2022 at "Cancer research"
DOI: 10.1158/0008-5472.can-22-0225
Abstract: Recent work has made it clear that pericentriolar material (PCM), the matrix of proteins surrounding centrioles, contributes to most functions of centrosomes. Given the occurrence of centrosome amplification in most solid tumors and the unconventional… read more here.
Keywords: pericentriolar material; centrosome amplification; pcm; proteomic mapping ... See more keywords
Type 2 Diabetes Promotes Cell Centrosome Amplification via AKT-ROS-Dependent Signalling of ROCK1 and 14-3-3σ
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DOI: 10.1159/000489812
Abstract: Background/Aims: Type 2 diabetes is associated with oxidative stress and DNA damage which can cause centrosome amplification. Thus, the study investigated centrosome amplification in type 2 diabetes and the underlying mechanisms. Methods: Centrosome numbers in… read more here.
Keywords: akt ros; ros dependent; type diabetes; centrosome amplification ... See more keywords