Centrosome Biology: Polymer-Based Centrosome Maturation
Sign Up to like & getrecommendations! Published in 2017 at "Current Biology"
DOI: 10.1016/j.cub.2017.07.036
Abstract: The molecular mechanisms that control how the centrosome increases in size and microtubule nucleation capacity during mitosis have remained elusive. Recent work using in vitro assays provide exciting clues as to how this may occur. read more here.
Keywords: based centrosome; centrosome biology; biology; biology polymer ... See more keywords
Aurora-A Breaks Symmetry in Contractile Actomyosin Networks Independently of Its Role in Centrosome Maturation.
Sign Up to like & getrecommendations! Published in 2019 at "Developmental cell"
DOI: 10.1016/j.devcel.2019.02.012
Abstract: Cell polarity is facilitated by a rearrangement of the actin cytoskeleton at the cell cortex. The program triggering the asymmetric remodeling of contractile actomyosin networks remains poorly understood. Here, we show that polarization of Caenorhabditis… read more here.
Keywords: cortical actomyosin; actomyosin; actomyosin networks; contractile actomyosin ... See more keywords
Plk1 Mediates Paxillin Phosphorylation (Ser-272), Centrosome Maturation, and Airway Smooth Muscle Layer Thickening in Allergic Asthma
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-43927-8
Abstract: Allergic asthma is characterized by airway smooth muscle layer thickening, which is largely attributed to cell division that requires the formation of centrosomes. Centrosomes play a pivotal role in regulating bipolar spindle formation and cell… read more here.
Keywords: plk1; muscle; smooth muscle; centrosome maturation ... See more keywords
Centrosome maturation - in tune with the cell cycle.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of cell science"
DOI: 10.1242/jcs.259395
Abstract: Centrosomes are the main microtubule-organizing centres, playing essential roles in the organization of the cytoskeleton during interphase, and in the mitotic spindle, which controls chromosome segregation, during cell division. Centrosomes also act as the basal… read more here.
Keywords: centrosome maturation; cell; maturation tune; cell cycle ... See more keywords
Evidence that a positive feedback loop drives centrosome maturation in fly embryos
Sign Up to like & getrecommendations! Published in 2019 at "eLife"
DOI: 10.7554/elife.50130
Abstract: Centrosomes are formed when mother centrioles recruit pericentriolar material (PCM) around themselves. The PCM expands dramatically as cells prepare to enter mitosis (a process termed centrosome maturation), but it is unclear how this expansion is… read more here.
Keywords: centrosome maturation; loop drives; positive feedback; maturation ... See more keywords