Modeling microcephaly with cerebral organoids reveals a WDR62–CEP170–KIF2A pathway promoting cilium disassembly in neural progenitors
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DOI: 10.1038/s41467-019-10497-2
Abstract: Primary microcephaly is caused by mutations in genes encoding centrosomal proteins including WDR62 and KIF2A. However, mechanisms underlying human microcephaly remain elusive. By creating mutant mice and human cerebral organoids, here we found that WDR62… read more here.
Keywords: cilium disassembly; cilium; cep170 kif2a; cerebral organoids ... See more keywords