Penicillin Binding Protein Substitutions Cooccur with Fluoroquinolone Resistance in Epidemic Lineages of Multidrug-Resistant Clostridioides difficile
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DOI: 10.1128/mbio.00243-23
Abstract: Fluoroquinolone and cephalosporin use in healthcare settings has triggered outbreaks of high-mortality, multidrug-resistant C. difficile infection. Here, we identify a mechanism associated with raised cephalosporin MICs in C. difficile comprising amino acid substitutions in two… read more here.
Keywords: fluoroquinolone resistance; cephalosporin; cephalosporin mics; multidrug resistant ... See more keywords